02852cam a2200349 a 4500 EG-GiCUC 20250223031722.0 170509s2016 ua d f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.11.28.M.Sc.2016.Di.T Dina Aly Abdelhay Troponin as an early marker for detection of cardiomyopathy in beta-thalassemia patients / Dina Aly Abdelhay ; Supervised Mona Hassan Eltagui , Marwa Farouk Mira , Heba Nabil Baz قياس نسبة انزيم التروبونين كعالمة مبكرة على اعتالل عضلة القلب فى مرضى انيميا البحر المتوسط Cairo : Dina Aly Abdelhay , 2016 119 P. : charts ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Heart disease remains the major cause of morbidity and mortality in thalassemic patients. Multiple pathologies have been suggested in the development of cardiac dysfunction in thalassemic patients including: iron overload in the heart, leading to RV diastolic then LV systolic dysfunction, chronic anemia and the tissue hypoxia it induces together with impair free fatty acid oxidation and ATP production in myocardial cells. Because congestive heart failure is the main cause of death in these patients, early recognition of cardiac dysfunction may be useful in modifying the therapy. Tissue doppler echocardiography and serum troponin level may be a promising tool for such a purpose. Thirty thalassemic patients with a mean age of 12.93±2.07 years and thirty aged matched healthy control subjects have been included in the study. Patients have been recruited from pediatric hematology clinics in both Cairo university. Conventional, TDI as well as conventional and M-Mode echogardiography was performed to all patients and control subjects in addition to myocardial relaxometry T2* by cardiac MRI and serum assays of troponin. Though no statistically significant difference was noted between cases and controls by conventional echocardiographic parameters, compared to normal subjects, we found by tissue doppler imaging that there is significant difference of Rv e'/a' ratio between cardiac and non-cardiac iron overloaded patients which reflects early diastolic dysfunction in cardiac iron overloaded patients Issued also as CD Iron load Myocardial affection Thalassemia Heba Nabil Baz , Supervisor Marwa Farouk Mira , Supervisor Mona Hassan Eltagui , Supervisor http://172.23.153.220/th.pdf Nazla Revisor Samia Cataloger ddc TH 60854 60854 ddc 0 CUCL cl210 2024-02-11 Cai01.11.28.M.Sc.2016.Di.T 01010110071649000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.11.28.M.Sc.2016.Di.T 01020110071649000 2023-09-22 00:00:00 71649.CD CD