Sana Maher Aghbary <br/><br/>
Evaluation of MicroRNA 27b and MicroRNA 137 as biomarkers of activity and malignant transformation in oral Lichen planus patients :   Clinical trial /  
 كموشرات حيوي للنشاط المرضى والتحول السرطانى في مرضى الحزاز الفموىmicroRNA137و  microRNA27b تققيم  
Sana Maher Aghbary ; Supervised Soheir Mohamed Gaafar , Olfat Gamil Shaker , Shahira Gamal Elashiry 
 - Cairo :   Sana Maher Aghbary ,   2012 
 - 98 , (39) P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Pathology 
<br/><br/> Oral lichen planus (OLP) is a chronic inflammatory muccocutaneous disease with a potential malignant transformation, characterized by cytotoxic T cell against basal epithelial cells. MicroRNAs (miRNAs) are a short non-coding RNA that plays a critical role in gene expression at post-transcriptional levels. Many evidence showed that miRNAs play an important role in regulating immune response and cancer development. The purpose of the present study to compare the expression of microRNA 27b and microRNA137 in tissues and saliva between OLP patients and controls, also, to evaluate their use as biomarkers of disease activity and malignant transformation by using real-time quantitative PCR. Our result showed down expression in miRNA27b and miRNA137 in tissue and saliva of OLP compared to control, denoting the role of miRNA27b and miRNA137 in the pathogenesis and potential malignant transformation of OLP. In conclusion, the down expression of salivary miRNA27b and miRNA137 favor the use of saliva sample as a noninvasive method for monitoring OLP activity and malignant transformation 
<br/><br/>
<br/><br/><label>Subjects--Index Terms: </label>MicroRNA 137 MiRNA27b  Oral lichen planus