Study of the effect of low level laser therapy on bone repair in rats /
دراسة تأثير الليزر المنخفض الشدة على إلتئام العظام فى الفئران
Ahmed Elprince Mohamed Ragab ; Supervised Yousry Mahmoud Mostafa , Nashwa Taher Abdelaziz , Ahmed Hassan Hussein
- Cairo : Ahmed Elprince Mohamed Ragab , 2018
- 101 P. : charts , facsimiles , photographs ; 25cm
Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Science - Department of Laser Applications on in Medical and Biological
Objective: This study was conducted to determine the effect of low level laser therapy (LLLT) on bone repair in rats. Materials and methods: Seventy two rats were assigned randomly into three groups, group (A) consisted of twenty four rats whose bone fracture didnt receive laser therapy, group (B) consisted of twenty four rats whose bone fracture received He-Ne laser (632.8 nm) and group (C) consisted of twenty four rats whose bone fracture received Ga-As laser (905 nm). Each group was subdivided into three subgroups according to their sacrificing day on 15th, 30th and 45th post-operative days. Assessment of bone fracture healing was done through radiological analysis and histopathological analysis. Results: The results of this study revealed that group (C) showed more complete bone regeneration on 15th and 30th post-operative days when compared with groups (A&B) according to the radiological findings. According to the histopathological analysis, on 15th and 30th postoperative days, there was no statistically significant difference between groups (A&B) (p > 0.05) in newly formed blood vessels, fibroblasts, osteiod and bone formation scores. While, there was a significant difference between groups (A&C) and (B&C) (p value < 0.05) in favor of group (C). Conclusion: Ga-As laser showed a bio-stimulating effect on the rate of bone repair by stimulating the modulation of the initial inflammatory response and anticipating the resolution to normal condition at the earlier periods. Both He-Ne and Ga-As lasers were not different from the control group on 45th postoperative day