A comparative study of TCA 35% and phenol 88% peels as monotherapy versus combination therapy with N-acetyl-L-cysteine in patchy alopecia areata : A trichoscopic evaluation /
تقييم التقشير بثلاثي حمض الخليك ثلاثي الكلور ٥٪ والفينول ٨٨٪ مقابل اقتران كل منهما على حدة بدواء إن أسيتيل سيستيين لعلاج الثعلبة البقعي: باستخدام التريكوسكوب
Riham Mohye Eldeen Mohamed Morsy ; Supervised Doaa Mohamed Ali Mahgoub , Sarah Ibrahim Ismail
- Cairo : Riham Mohye Eldeen Mohamed Morsy , 2018
- 146 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology
Background: Alopecia areata (AA) is a tissue-specific autoimmune disorder wherein anagen hair follicles sustain a T-cell-mediated inflammatory assault. It commonly presents with circumscribed patches of non-scarring hair loss. It implies a significant psychosocial burden. A myriad of therapeutic modalities are available for the treatment of AA, but none has yet proven uniformly effective. Chemical peeling can potentially be used in the treatment of AA; primarily acting via therapeutic wounding with subsequent release of growth factors and cytokines. Aim of work: To evaluate the efficacy, safety, and tolerability of TCA 35% peel in comparison to phenol peel 88% in AA treatment, to determine whether oral N-acetyl-L-cysteine (NALC) has an additive value to chemical peels in subjects with AA, and to assess the impact of these interventions on patients quality of life. Methodology: A total of 20 patients with multifocal patchy AA of the scalp (2 patches) were enrolled,wherein a total of 40 patches were subjected to chemical peeling byTCA 35% and phenol 88%; each applied to a distinct patch in the same individual, respectively, in tandem, on 3-weekly basis for 3 consecutive months. Within the studied group, subjects were further randomized to two equal Groups; either Group A (Chemoexfoliation monotherapy) or Group B (Chemoexfoliation combined with oral NALC).Comparative assessment was carried out utilizing trichoscopic scaled scores of dystrophic and terminal hairs, respectively, SALT score, DLQI score as well as the global patients satisfaction scaled score. Adverse effects were monitored clinically, trichoscopically, and via direct questioning
Chemical peeling Multifocal patchy alopecia areata TCA 35%