TY  - BOOK
AU  - Nehal Mohamed Nabil Elbakhshawangy
AU  - Asmaa Elsayed Abdellatief Kassab , 
AU  - Azza Taher Taher Shalaby , 
AU  - Hala Bakr Ali Elnassan , 
TI  - Synthesis of novel oxadiazole and chromene derivatives as cytotoxic agents / 
PY  - 2018///
CY  - Cairo : 
PB  - Nehal Mohamed Nabil Elbakhshawangy , 
KW  - Chromene derivatives
KW  - Cytotoxic agents
KW  - Novel oxadiazole
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry; Issued also as CD
N2  - The design and synthesis of 1,3,4-oxadiazoles and chromenopyrimidines as microtubule destabilizing agents has been explained. The newly synthesized compounds were evaluated for their cytotoxicity against MCF-7 cell line. All the prepared chromenopyrimidines showed potent cytotoxic activity. Compound XVb was the leading compound as it showed IC₅₀ values of 0.13 oM on tumor cell line MCF-7 (11-fold more active than the reference drug colchicine) and 14.06 oM on mammary epithelial cell line MCF-10A. Also, it inhibited tubulin polymerization (IC₅₀ = 8.36oM), caused cell cycle arrest at G2/M phase (five folds more than control) and cellular apoptosis. Moreover, it increased the level of active caspase-3, 12-fold compared with control
UR  - http://172.23.153.220/th.pdf
ER  -