03102cam a2200349 a 4500 EG-GiCUC 20250223032157.0 190131s2018 ua dh f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.11.02.M.Sc.2018.Ba.C Basma Emad Mohamed Saad Cardioprotective role of citratein streptozotocin- induced diabetes in adult male albino rat : Morphological and immunohistochemical study / Basma Emad Mohamed Saad ; Supervised Mohamed Emad Eldin Ibrahim , Hanan Nabih Gadallah , Reda Abdelnasser Imam الدور الوقائي للسيتريت علي القلب في داء السكري المستحث بعقار الستربتوزوتوسين في ذكر الفأر الابيض البالغ : دراسه مورفولوجيه وهستوكيميائيه مناعيه Cairo : Basma Emad Mohamed Saad , 2018 131 P. : charts , facsimiles ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Anatomy Objectives:Diabetes mellitus is a chronic disease associated with hyperglycemia and oxidative stress which cause several tissue damage in many organs including the heart.Diabetic cardiomyopathy, as an independent cardiac complication, is characterized by myocardial dysfunction in the absence of coronary artery disease, hypertension or valvular heart disease. The present study aimed to investigate the cardiac histopathological changes of streptozotocin(STZ)-induced diabetes in adult male albino rats and the possible protective role of citrate. Methods: This study was carried out on 45 male albino rats which were divided into group I ( Non-diabetic control group) fifteen rats received no medication ,group II (Diabetic group) fifteen rats received single intraperitoneal injection of 50 mg/kg bw STZ , group III (Prophylactic group) Ten diabetic rats received 5 og/kg sodium citrate every other day by intraperitoneal injections immediately after induction of diabetes and group IVc (Therapeutic group) Five diabetic rats received 5 og/kg sodium citrate every other day by intraperitoneal injections three weeks after induction of diabetes then were sacrificed 5 weeks later.Blood samples were collected from the tail vein for determination of blood glucose level.Then the rats were sacrificed and the heart was carefully removed. Parts of the hearts obtained were prepared and used to determine glutathione (GSH) and malondialdhyde (MDA) levels.The remaining parts of hearts were prepared for light microscopic and histomorphometric studies Issued also as CD Diabetes mellitus Heart Streptozotocin Hanan Nabih Gadallah , Supervisor Mohamed EmadEldin Ibrahim , Supervisor Reda Abdelnasser Imam , Supervisor http://172.23.153.220/th.pdf Nazla Revisor Shimaa Cataloger ddc TH 69870 69870 ddc 0 CUCL cl210 2024-02-11 Cai01.11.02.M.Sc.2018.Ba.C 01010110077036000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.11.02.M.Sc.2018.Ba.C 01020110077036000 2023-09-22 00:00:00 77036.CD CD