02833cam a2200349 a 4500 EG-GiCUC 20250223032211.0 190219s2018 ua h f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite Ph.D Cai01.24.03.Ph.D.2018.Is.S Islam Mohamed Noaman Mohamed Study of the treatment of cutaneous fungal infection in animal model using photoactivated composite of methylene blue and metal nanoparticle / Islam Mohamed Noaman Mohamed ; Supervised Mona Mohamed Soliman , Abeer Attia Tawfik ,Hassan Ibraheem H. Elsayyad علاج الفطريات الجلدية في نموذج حيواني باستخدام مركب الميثيلين الأزرق وجسيمات النانو المعدنية المستحثة بالضوء Cairo : Islam Mohamed Noaman Mohamed , 2018 78 P. : facsimiles ; 25cm Thesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Sciences - Department of Laser Applications in Medical and Biological Background: Onychomycosis is a widespread public health problem, in which T. rubrum and T. mentagro-phytes is the commenest causative organisms. Current medical therapy has many drawbacks and sideeffects. Methylene blue (m.b) photodynamic therapy (pdt) proved efficacy but with lengthy sessions.Objectives: Optimizing methylene blue photodynamic therapy by combination of methylene blue pho-tosensitizer and gold nanoparticles (aunps) in a composite as gold nanoparticles are efficient delivery systems and efficient enhancers of photosensitizers for antifungal photodynamic therapy. Materials and methods: Eighty newzealand rabbit (Oryctolagus cuniculus) were used and categorized ineight equal groups as follows; healthy and infection control, composite photodynamic therapy and five comparative groups. Photodynamic therapy was initiated at day three to five post inoculation, for four sessions forty-eight hours apart. Each group divided and light exposure at two fluencies; 80 J and 100 J. All groups were investigated macroscopically and microscopically (histopathology and scanning electron microscope) also flowcytometry assessment for cell death and X-ray analysis for gold nanoparticles accumulation in brain and liver tissues were determined Issued also as CD Dermatophytosis Methylene blue photodynamic therapy Onychomycosis Abeer Attia Tawfik , Supervisor Hassan Ibraheem H. Elsayyad , Supervisor Mona Mohamed Soliman , Supervisor http://172.23.153.220/th.pdf Asmaa Cataloger Nazla Revisor ddc TH 70329 70329 ddc 0 CUCL cl210 2024-02-11 Cai01.24.03.Ph.D.2018.Is.S 01010110077084000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.24.03.Ph.D.2018.Is.S 01020110077084000 2023-09-22 00:00:00 77084.CD CD