Amr Muhammed Rakha <br/><br/>
Oxidative stress status and dna damage on occupational exposure to polycyclic aromatic hydrocarbons among coal tar workers /  
 التوتر التأكسدي و تضرر الحمض النووى مع التعرض المهني للبولي اروماتك هيدروكاربونات في عمال قطران الفحم 
Amr Muhammed Rakha ; Supervised Sawsan Farouk Helal , Laila Ahmed Rashed , Rehab Shehata Abdelhady 
 - Cairo :   Amr Muhammed Rakha ,   2018 
 - 203 P. :   charts , facsimiles ;   25cm  
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Industrial and Occupational Disease 
<br/><br/> Introduction: Polyaromatic hydrocarbons (PAHs) are of occupational and environmental concern as they are toxic, carcinogenic, mutagenic, and/or teratogenic (causing birth defects) and even are probable human carcinogens.Objective: To assess the health effects of occupational exposure to PAHs on DNA damage and oxidative stress. Methods: A group of 40 coal tar workers and another 40 matched control were subjected to full history and clinical examination,estimation of 1-hydroxypyrene (1-OHPyrene) level in urine, Benzopyrene-DNA adducts, oxidative stress enzymes (Superoxide dismutase and glutathione peroxidase),Cytochrome P450 and Complete blood picture. Results: Statistically significant higher level of 1-OHPyrene, DNA adducts and lower levels of superoxide dismutase and glutathione peroxidase were detected among the exposed workers compared to the control group. Conclusion: oxidative stress and DNA damage might be among the hazards that can be attributed to occupational exposure to PAHs among coal tar workers 
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<br/><br/><label>Subjects--Index Terms: </label>1-Hydroxypyrene  Coal tar production Polycyclic aromatic hydrocarbons