TY  - GEN
AU  - Ehab Fathi Gabr Aboueladab
AU  - Abdelgawad Fahmi , 
AU  - Joesef Brock , 
AU  - Mohamed Ali Eldesokey , 
TI  - Galectin - 1 stimulated signaling events in T - lymphocytes / 
PY  - 2006///
CY  - Cairo : 
PB  - Ehab Fathi Gabr Aboueladab , 
KW  - Apoptosis
KW  - Galectin - 1
KW  - T - cells
N1  - Thesis (PH.D.) - Cairo University - Faculty Of Science - Department Of Biochemistry; Issued also as CD
N2  - This work has been carried out to investigate the mechanisms of T cell activation on the level of signal transduction induced by galectin - 1 (gal - 1) having immunosuppressive activityGal - 1 recognizes and cross - links appropriate glycoepitopes (Gal?1 - 4GlcNAc - sequences) on T cell activation markers (CD2 , CD3 , CD45) and stimulates in parallel several interacting signalling pathways leading to suppression of the expression of Th1 cytokines and to apoptosis in thymocytes , activated T - cells , and in leukemic T cell linesIn cellular models by applying cell - and glycobiological methods we have focused on gal - 1 induced or suppressed signalling pathways involved in inhibition of a processive immune response of antigen - stimulated T lymphocytesIn this way , by depletion of activated T cells gal - 1 is a negative regulator of the immune responseTherefore , the mechanism of gal - 1 induced T cell apoptosis is of special interest
UR  - http://172.23.153.220/th.pdf
ER  -