02697cam a2200349 a 4500 EG-GiCUC 20250223032255.0 190505s2018 ua dho f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite Ph.D Cai01.24.03.Ph.D.2018.Sh.E Shahenda Ahmad Ramez Evaluation of the topical delivery of methotrexate combined with fractional erbium : YAG laser in the treatment of plaque psoriasis / Shahenda Ahmad Ramez ; Supervised Mona Mohamed Soliman , Maha Fadel Mohamed Ali , Faisal Nour Eldeen Mohamed تقيين التوصيل الموضعى للميثوتريكسات مع الإربيوم ياج ليزر المجزأ فى علاج الصدفية اللويحية Cairo : Shahenda Ahmad Ramez , 2018 88 P. : charts , facsimiles , photoghraphs ; 25cm Thesis (Ph.D.) - Cairo University - National Institute of Enhanced Laser Sciences - Department of Laser Applications in Medical and Biological Psoriasis is a commonly encountered chronic dermatological disease, presenting with inflammatory symptoms in patients. Systemic treatment of psoriasis is associated with several adverse effects; therefore the development of a customized topical treatment modality for psoriasis would be an interesting alternative to systemic delivery. The therapeutic modality explored in this study was the comparative treatment of psoriatic patients using nanoparticulated methotrexate in the form of jojoba oil based microemulsion with or without fractional erbium YAG laser. Assessment parameters included follow up photography for up to 8 weeks of treatment, estimation of the psoriasis severity score of the treated lesions which is the score of thickness, erythema, scales (TES score), and histopathological skin evaluation. Results revealed that the prepared methotrexate microemulsion was clinically beneficial and safe in treatment of psoriasis vulgaris. The concomitant use of the fractional laser provided improvement in the psoriatic plaques within shorter time duration (3 weeks compared to 8 weeks of treatment), presenting an alternative topical treatment modality for psoriasis vulgaris Issued also as CD Methotrexate Nanocarrier Psoriasis Faisal Nour Eldeen Mohamed , Supervisor Maha Fadel Mohamed Ali , Supervisor Mona Mohamed Soliman , Supervisor http://172.23.153.220/th.pdf Nazla Revisor Shimaa Cataloger ddc TH 71801 71801 ddc 0 CUCL cl210 2024-02-11 Cai01.24.03.Ph.D.2018.Sh.E 01010110077987000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.24.03.Ph.D.2018.Sh.E 01020110077987000 2023-09-22 00:00:00 77987.CD CD