Some pharmacological and toxicological studies on some constituents of apricot seeds /
بعض الدراسات الفارماكولوجية والسمية علي بعض مكونات بذور المشمش
Aya Abdelsalam Aboelola Shokry ; Supervised Gehan Mohamed Kamel , Nagwa Elsayed Ahmed Awad
- Cairo : Aya Abdelsalam Aboelola Shokry , 2018
- 188 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology
The present study aimed to investigate some phytochemical, toxicological and pharmacological activities of ethanolic apricot seeds extracts. Different phytochemicals were analyzed. The phytochemical screening was done for determination of total phenolic compounds by FolinCiocalteu method, total flavonoids by aluminum chloride colorimetric method, total carotenoids by colorimetric method and amygdalin content by using HPLC. The anti-inflammatory activity and total antioxidant capacity of the extracts were done. The anti-inflammatory activity was done in vitro by determination of the half maximal inhibitory concentration (IC50) values for inhibition of the enzymes cyclooxygenase 1, 2 (COX-1, COX-2). The total antioxidant capacity was determined by determination of DPPH (1, 1-diphenyl-2-picryl-hydrazyl) radical scavenging activity. The in-vitro cytotoxicity of extracts on normal human lung cell line and liver cancer cells (HepG2) was determined. The toxicological studies (Acute toxicity) of 70% and 99.9% ethanolic extracts were investigated