TY  - BOOK
AU  - Yasmine Farid Ahmed Abdelall
AU  - Elsayeda Ahmed Elkashoury , 
AU  - Meselhy Ragab Meselhy , 
AU  - Mouchira Ali Choucry , 
TI  - A pharmacognostical Study of cymbopogon citratus (DC.) stapf : : Family poaceae, cultivated in Egypt / 
PY  - 2018///
CY  - Cairo : 
PB  - Yasmine Farid Ahmed Abdelall , 
KW  - Alzheimer's disease
KW  - Botanical study
KW  - Cymbopogon citratus
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy; Issued also as CD
N2  - Cymbopogon is one of the largest genera in family poaceae. It is indigenous to tropical and sub-tropical regions of Asia, Africa and America. Cymbopogon citratus is one of the most important essential oil-bearing species of the genus. A botanical study of C. citratus leaves, culm, rhizome and roots was carried out. Phytochemical study of the leaves was performed including preliminary phytochemical screening, proximate analysis, UPLC-HRMS profiling of the secondary metabolites, quantitative estimation of the total phenolic and flavonoid contents, as well as investigation of the lipoidal composition. A biologically guided study of the leaf extracts revealed the prevalence of the ethanolic extract over the aqueous as neuroprotective in-vivo against AlCl3-induced alzheimer's disease through regression of the hallmark proteins, as well as oxidative stress and inflammatory mediators. Moreover, the Diaion 50% methanol fraction of the ethanolic extract was found the most active in-vitro both as antioxidant and acetylcholinesterase inhibitor. Chemical investigation of this fraction led, for the first time, to the isolation of luteolin-7-O-neohesperidoside and isoschaftoside from genus Cymbopogon, besides isoorientin and luteolin-7-O-glucoside. HPLC standardization of the active fraction was performed using the major detected phenolic acids and flavones as chemical markers
UR  - http://172.23.153.220/th.pdf
ER  -