02315cam a2200349 a 4500 EG-GiCUC 20250223032322.0 190704s2018 ua dh f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.11.28.M.Sc.2018.Mo.A Mohamed Hamdy Afify Abdelmaksoud Affection of cardiac functions in patients with nephropathic cystinosis / Mohamed Hamdy Afify Abdelmaksoud ; Supervised Neveen Abdelmonem Soliman , Usama Mohamed Abdelaziz , Safaa Mohamed AbdelRahman بيان مدى تأثر وظائف القلب فى مرضى السيستين الكلوى Cairo : Mohamed Hamdy Afify Abdelmaksoud , 2018 82 P. : charts , facsimiles ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Nephropathic cystinosis is a rare genetic disease characterized by accumulation of the amino acid cystine in lysosomes throughout the body. The main objective of this study is evaluation of cardiac function in cystinosis patients using non- conventional echocardiographic modalities like Tissue Doppler Imaging (TDI) and 2D speckle tracking echocardiography. Methods: This is a case control study that was conducted on fifteen patients with cystinosis and 15 normal controls. Echocardiography was done for all participants and Pulsed Wave Tissue Doppler Imaging (PW-TDI) was performed for measurement of S', E' velocities and myocardial performance index (MPI) at basal parts of septal, left ventricle (LV) and right ventricle (RV) free walls. 2D-STE was done for evaluation of global longitudinal strain (GLS), global circumferential strain (GCS) and global radial strain (GRS) of LV. Mitral E and A velocities and tricuspid annular plan systolic excursion (TAPSE) were also measured Issued also as CD 2D-STE Cystinosis TDI Neveen Abdelmonem Soliman , Supervisor Safaa Mohamed AbdelRahman , Supervisor Usama Mohamed Abdelaziz , Supervisor http://172.23.153.220/th.pdf Asmaa Cataloger Nazla Revisor ddc TH 72658 72658 ddc 0 CUCL cl210 2024-02-11 Cai01.11.28.M.Sc.2018.Mo.A 01010110078541000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.11.28.M.Sc.2018.Mo.A 01020110078541000 2023-09-22 00:00:00 78541.CD CD