03009cam a2200337 a 4500 EG-GiCUC 20250223032431.0 191105s2018 ua dh f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.11.28.M.Sc.2018.Me.B Menna Allah Mohamed Moghawry Basophil count as a marker of disease activity in Egyptian children with juvenile systemic lupus erythematous / Menna Allah Mohamed Moghawry ; Supervised Heba Taher Othman , Amr Mohamed Salem عدد كرات الدم القاعدية كمؤشر لنشاط مرض الذئبه الحمراء فى الاطفال المصريين المصابين بمرض الذئبة الحمراء فى مستشفى الأطفال - جامعة القاهرة Cairo : Menna Allah Mohamed Moghawry , 2018 118 P. : charts , facsimiles ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Introduction: Systemic lupus erythematosus (SLE) is a multisystem autoimmune connective tissue disease, 20% of cases having their onset in childhood and are classified as juvenile-onset SLE (JSLE). Objective: The aim of this work is to assess the basophilic count as a marker for disease activity in JSLE to enable the earlier diagnosis and treatment of SLE flares. Patients and methods: This cross-sectional cohort study was conducted on 80 children with JSLE following at pediatric rheumatology clinic, Specialized Children{u2019}s hospital, Cairo University and compared to 100 healthy children as a control group. SLEDAI-2K score was done at time of the study, together with CBC with differential to evaluate basophilic count. Results: The mean age of disease onset was 9.14 ± 2.23 years. Among the clinical manifestations at presentation, arthritis and malar rash (37.5% each) were the most common. Throughout the course of the disease malar rash (70%) and nephritis (67.5%) were the most common disease manifestations. Thirty-eight patients (70.3%) did renal biopsy to diagnose nephritis. Basophil counts were similar in patients with SLE and healthy controls (0.0±0.04x109/L), p value =0.06) and was within normal range. Basophils absolute count was within normal range (0 - 0.1x 109 /L) in most of our patients. There was relative basophilia in active patients{u2019} group which increased with higher SLEDAI-2K score but with no statistical significance basophil counts were (0.01± 0.03x109/L) in SLEDAI-2K score (4-8) and were (0.03±0.07X109/L) in SLEDAI-2K score more than 8 Issued also as CD Basophil counts Disease activity Marker Amr Mohamed Salem , Supervisor Heba Taher Othman , Supervisor http://172.23.153.220/th.pdf Nazla Revisor Samia Cataloger ddc TH 75005 75005 ddc 0 CUCL cl210 2024-02-11 Cai01.11.28.M.Sc.2018.Me.B 01010110079744000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.11.28.M.Sc.2018.Me.B 01020110079744000 2023-09-22 00:00:00 79744.CD CD