Hadya Nabil Ezzat Mohamed Ghedan <br/><br/>
Detection of cancer stem cells in the most common head and neck non-hodgkins lymphoma using CD34 :   In vitro study /  
 الكشف عن الخلايا الجذعية للسرطان فى الأورام الليمفاوية غير هودجكين الأكثر شيوعا فى الرأس و الرقبة باستخدام سى دى34 :   دراسة فى المختبر 
Hadya Nabil Ezzat Mohamed Ghedan ; Supervised Samia Mostafa Elazab , Safa Fathy Abdelghany , Mona Aly Saker 
 - Cairo :   Hadya Nabil Ezzat Mohamed Ghedan ,   2016 
 - 63 P. :   photographs ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral and Maxillofacial Pathology 
<br/><br/> Background. Non-hodgkin lymphomas (NHL) are a heterogeneous group of malignancies of the immune system; diffuse large B-cell lymphoma and Burkitts lymphoma are among its most common subtypes. Recently, it is widely believed that cancer stem cells play critical roles in the initiation, metastasis, and relapse of cancers. However, no sufficient data supported the presence of cancer stem cells in NHL of the head and neck. Purpose. To detect cancer stem cells in diffuse large B-cell lymphoma and Burkitts lymphoma using immunohistochemical expression CD34, a widely used marker for identification and detection of hematopoietic stem cells. Methodology. The present work was performed on archival paraffin blocks of diffuse large B-cell lymphoma and Burkitts lymphoma. The mean count and mean area of the positive CD34 cells were assessed by the image analyzer computer system using the software Leica Qwin 500. Results. The results showed positive CD34 immunoreaction in 90% of the diffuse large B-cell lymphoma cases, and 70%of the Burkitts lymphoma cases, denoting presence of cancer stem cells in both tumors. Diffuse large B-cell lymphoma showed significantly higher mean count and mean area of positive CD34 cells than those of Burkitts lymphoma 
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<br/><br/><label>Subjects--Index Terms: </label>Cancer stem cells CD34 Non-hodgkins lymphoma B-Cell lymphoma and burkitts lymphoma