Maha Mohammed Farid Ahmed <br/><br/>
Performance of nanohydroxapatite in overcoming the acute renal failure induced by cisplatin in male rats /  
 أداء النانوهيدروكسى أباتيت فى التغلب على الفشل الكلوى الحاد الناجم عن السيسبلاتين فى ذكور الجرذان 
Maha Mohammed Farid Ahmed ; Supervised Elsayed Fahim Elsayed Taha , Eman Ismaiel Abdelgawad 
 - Cairo :   Maha Mohammed Farid Ahmed ,   2020 
 - 109 P. :   charts , facsimiles ;   25cm  
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology 
<br/><br/> A population of rats was divided into four groups: Group1 injected intrapretioneal with saline, Group2 injected intravenously weekly with 100 mg/kg b.w. for three weeks, Group3 injected i.p. once with 5 mg/kg b.w. CDDP and Group4 received CDDP plus nano-HAp. In tissues, DNA fragmentation, kim 1 and histopathological were performed. In serum, NGAL,TNF-Ü, MCP-1, IL-10, BUN, creatinine, Na and K were measured.The results revealed that uptake of CDDP caused acute kidney injury.The treatment with nano-HAp repaired efficiently the fragmented DNA and ameliorated the most of investigated parameters.The histopathological observation was in agreement with biochemical results.In conclusion, nano-HAp succeeded in handling the symptoms of AKI and produced a new hope for patients to get treatment safe, fast and effective 
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<br/><br/><label>Subjects--Index Terms: </label>Acute kidney injury  Cisplatin  Nanohydroxyapatite