TY  - BOOK
AU  - Maha Mohammed Farid Ahmed
AU  - Elsayed Fahim Elsayed Taha , 
AU  - Eman Ismaiel Abdelgawad , 
TI  - Performance of nanohydroxapatite in overcoming the acute renal failure induced by cisplatin in male rats / 
PY  - 2020///
CY  - Cairo : 
PB  - Maha Mohammed Farid Ahmed , 
KW  - Acute kidney injury
KW  - Cisplatin
KW  - Nanohydroxyapatite
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology; Issued also as CD
N2  - A population of rats was divided into four groups: Group1 injected intrapretioneal with saline, Group2 injected intravenously weekly with 100 mg/kg b.w. for three weeks, Group3 injected i.p. once with 5 mg/kg b.w. CDDP and Group4 received CDDP plus nano-HAp. In tissues, DNA fragmentation, kim 1 and histopathological were performed. In serum, NGAL,TNF-Ü, MCP-1, IL-10, BUN, creatinine, Na and K were measured.The results revealed that uptake of CDDP caused acute kidney injury.The treatment with nano-HAp repaired efficiently the fragmented DNA and ameliorated the most of investigated parameters.The histopathological observation was in agreement with biochemical results.In conclusion, nano-HAp succeeded in handling the symptoms of AKI and produced a new hope for patients to get treatment safe, fast and effective
UR  - http://172.23.153.220/th.pdf
ER  -