03026cam a2200349 a 4500 EG-GiCUC 20250223032600.0 200917s2020 ua d f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite Ph.D Cai01.07.03.Ph.D.2020.Mo.D Mohamed Attia Ahmed Awad Detection of candidate genes associated with milk production traits in Egyptian buffalo / Mohamed Attia Ahmed Awad ; Supervised Samy Abou-bakr Mahmoud Mohamed , Hamdy Abdelshafy Abdraboh Hanafy , Salah Eldin Sayed Mohamed Elassal تحد{u٠٦أأ}د الج{u٠٦أأ}نات المرشحة للإرتباط بصفات إنتاج اللبن فى الجاموس المصرى Cairo : Mohamed Attia Ahmed Awad , 2020 198 P. : charts ; 25cm Thesis (Ph.D.) - Cairo University - Faculty of Agriculture - Department of Animal Production The aim of this study was to perform a genome-wide association study (GWAS) to identify genomic loci and detect potentially candidate genes associated with seven milk production traits; daily milk yield (DMY), fat percentage (FP), fat yield (FY), protein percentage (PP), protein yield (PY), lactose percentage (LP) and lactose yield (LY) in Egyptian buffalo. The phenotypic dataset included 161,479 daily milk records from 1,670 animals and 60,318 monthly measures for other traits from 1481 animals. Adjustment for non-genetic effects has been made using univariate animal model by BLUPF90. A total number of 114 animals with high and low deviated performance were selected for genotyping with Axiom Buffalo Genotyping 90K Array. Adjusted phenotypes were used for GWAS in the way of SNP-by-SNP using a single marker regression. With 5% Bonferroni genome-wide threshold, 55 significant and 33 suggestive SNPs were detected for association with the tested traits and were distributed over 25 buffalo chromosomes (BBU). The 88 SNPs were two for DMY, three for FP, seven for FY, 21 for PP, 14 for PY, 39 for LP and two for LY. The identified genomic regions were coincided with previously reported QTL in buffalo and cattle populations. In addition, novel genomic loci were suggested. The identified SNPs are placed within or close to many promising candidate genes with biological roles associated with milk production traits, for example:, TPD52, ZBTB10, RALYL, and SNX16 on BBU15; ADGRD1 on BBU17; ESRRG on BBU5; and GRIP1 on BBU4. This is the first GWAS for milk quality traits in Egyptian buffalo Issued also as CD Egyptian buffalo GWAS Milk traits Hamdy Abdelshafy Abdraboh Hanafy , Supervisor Salah Eldin Sayed Mohamed Elassal , Supervisor Samy Abou-bakr Mahmoud Mohamed , Supervisor http://172.23.153.220/th.pdf Amira Cataloger Nazla Revisor ddc TH 77814 77814 ddc 0 CUCL cl210 2024-02-11 Cai01.07.03.Ph.D.2020.Mo.D 01010110081519000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.07.03.Ph.D.2020.Mo.D 01020110081519000 2023-09-22 00:00:00 81519.CD CD