Analytical study of some pharmaceutical compounds containing heterocyclic rings /
دراسة تحليليه لبعض المركبات الصيدلية المحتوية على الحلقات الغير المتجانسة
Ola Gamal Hussein ; Supervised Mohamed Abdelkawy , Hala Elsayed Zaazaa , Eman Saad Elzanfaly
- Cairo : Ola Gamal Hussein , 2021
- 224 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry
Multicomponent formulations have gained a lot of importance nowadays due to greater patient acceptability, increase potency, multiple action, and quick relief. Simultaneous determination of drugs in combination is an important part in the field of pharmacy as it avoids time of extraction, separation and gets accurate and precise results. Analysis of impurities is very important in the pharmaceutical industry.The possibility of side and toxic effects, and reduced activity of the active substances must be reduced to a minimum. For this reason, different analytical methods were developed to determine Phenazopyridine and Trimethoprim in the presence of Phenazopyridine impurity (2,6-DAP). Most pharmaceutical compounds are subjected to degradation with the subsequent partial or even complete loss of pharmacological activity or the conversion to harmful or toxic substances. A stability indicating procedure may be defined as a procedure that affords selective determination of drug in presence of its degradation products. Thus the development of stability indicating assay has increased enormously. In this thesis, different analytical techniques, namely, spectrophotometry, chemometry, chromatography and voltammetry were developed to determine binary mixture of Phenazopyridine and Trimethoprim in the presence of Phenazopyridine impurity (2,6-DAP).Stability indicating second derivative (2D) spectrophotometry, TLC- densitometry, and voltammetry, were developed to determine Alcaftadine
Active Pharmaceutical Ingredients (APIs) Heterocyclic rings Pharmaceutical compounds