03578cam a2200349 a 4500 EG-GiCUC 20250223032720.0 210327s2021 ua d f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.08.03.M.Sc.2021.Mi.A Mina Wadie Ibrahim Analytical study of some drugs treating benign prostatic hyperplasia / Mina Wadie Ibrahim ; Supervised Ezzat Mohamed Abdelmoety , Soheir Abdelfattah Ahmed Omar , Mamdouh Reda Rezk دراسة تحليلية لبعض الأدوية المعالجة لتضخم البروستاتا الحميد Cairo : Mina Wadie Ibrahim , 2021 421 P. : charts ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry This thesis is concerned with the quantitative determination of some drugs used for treatment of benign prostatic hyperplasia and other coincident diseases. In this thesis, two binary mixtures were studied, separately, in their new pharmaceutical formulations. The first mixture contains Tamsulosin Hydrochloride (TAM) and Tadalafil (TAD), while the second one contains Alfuzosin Hydrochloride (ALF) and Solifenacin Succinate (SOL).The aim of this work was to develop different analytical methods that are characterized by simplicity, accuracy and appropriate degree of sensitivity for the analysis of the above-mentioned drugs in their pure forms, in their pharmaceutical formulations and in the presence of their degradation products and/or potential impurities. Smart UV-spectrophotometric, high-performance thin layer chromatographic (HPTLC) and high-performance liquid chromatographic (HPLC) methods were developed for the analysis of the first mixture (TAM and TAD). Moreover, the principles of green chemistry and Quality-by-Design approach were successfully implemented throughout the chromatographic separation.The greenness profile was assessed via several green metrics as GlaxoSmithKline solvent sustainability guide, environmental, health and safety (EHS) tool, national environmental methods index (NEMI) and Eco-Scale. Additionally, the stability of the two cited drugs was investigated under different stress conditions in accordance with ICH guidelines followed by developing stability-indicating high-performance thin layer chromatographic and high-performance liquid chromatographic methods.The second mixture (ALF and SOL) was assayed by eco-friendly UV-spectrophotometric and Quality-by-Design based HPLC methods in their binary mixtures. In addition, the two enantiomers of ALF were successfully separated along with SOL using 50-mm chiral column and ethanol as green organic solvent.The method was statistically optimized through experimental design. Moreover, stability-indicating high-performance thin layer chromatographic and high-performance liquid chromatographic methods were developed for the simultaneous determination of Alf and SOL along with their official impurities induced via stress stability studies Issued also as CD Alfuzosin hydrochloride Chromatography Experimental design Ezzat Mohamed Abdelmoety , Supervisor Mamdouh Reda Rezk , Supervisor Soheir Abdelfattah Ahmed Omar , Supervisor http://172.23.153.220/th.pdf Nazla Revisor Shimaa Cataloger ddc TH 80387 80387 ddc 0 CUCL cl210 2024-02-11 Cai01.08.03.M.Sc.2021.Mi.A 01010110083033000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.08.03.M.Sc.2021.Mi.A 01020110083033000 2023-09-22 00:00:00 83033.CD CD