03103cam a2200337 a 4500 EG-GiCUC 20250223032728.0 210414s2021 ua dh f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.08.09.M.Sc.2021.Me.P Merhan Ossama Abdelghany Hindam Possible neuroprotective effects of the coumarins : Xanthotoxin and umbelliferone in the model of streptozotocin-induced sporadic Alzheimer{u2019}s disease in rats / Merhan Ossama Abdelghany Hindam ; Supervised Nesrine S. Elsayed , Rabab Hamed Sayed زانثوتوكسين و امبيلليفرون في النموذج المحدث به مرض الزهايمر المنتشر بفعل استربتوزوتوسين في الجرذان : التأثيرات الممكنة الوقائية للأعصاب لكومارينز Cairo : Merhan Ossama Abdelghany Hindam , 2021 148 P . : charts , facsmilies ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology The aim of the present study was to assess the neuroprotective effects of xanthotoxin and umbelliferone in streptozotocin (STZ)-induced cognitive dysfunction in rats. Animals were injected intracerebroventricularly (ICV) with STZ (3 mg/kg) once to induce a sporadic Alzheimer's disease (SAD)-like condition. Xanthotoxin or umbelliferone (15 mg/kg, i.p.) were administered 5 hr after ICV-STZ and daily for 20 consecutive days. Xanthotoxin or umbelliferone prevented cognitive deficits in the Morris water maze and object recognition tests. In parallel, xanthotoxin or umbelliferone reduced hippocampal acetylcholinestrase activity and malondialdehyde level. Moreover, xanthotoxin or umbelliferone increased glutathione content. These coumarins also modulated neuronal cell death by reducing the level of proinflammatory cytokines) tumour necrosis factor-alpha and interleukin-6), inhibiting the overexpression of inflammatory markers (nuclear factor mB [NF-mB] and cyclooxygenase II), and upregulating the expression of NF-mB inhibitor (ImB-Ü). Interestingly, xanthotoxin diminished phosphorylated JAK2 and phosphorylated STAT3 protein expression, while umbelliferone markedly replenished nuclear factor erythroid-derived 2-like 2 (Nrf2) and haem oxygenase-1 (HO-1) levels. The current study provides evidence for the protective effect of xanthotoxin and umbelliferone in STZ-induced cognitive dysfunction in rats. This effect may be attributed, at least in part, to inhibiting acetylcholinestrase and attenuating oxidative stress, neuroinflammation and neuronal loss. Issued also as CD Alzheimer's disease Umbelliferone Xanthotoxin Nesrine S. Elsayed , Supervisor Rabab Hamed Sayed , Supervisor http://172.23.153.220/th.pdf Amira Cataloger Nazla Revisor ddc TH 80650 80650 ddc 0 CUCL cl210 2024-02-11 Cai01.08.09.M.Sc.2021.Me.P 01010110083262000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.08.09.M.Sc.2021.Me.P 01020110083262000 2023-09-22 00:00:00 83262.CD CD