Clinical and immunohistochemical evaluation of the cancer chemopreventive effect of thymoquinone compared to a placebo on oral potentially malignant lesions among an egyptian population : A randomized clinical trial /
تجربة طبية عشوائية : التقييم السريرى و الهستوكميائى المناعى للتاثير الوقاى الكيميائى للثيموكينون ضد السرطان مقارنة بالدواء الوهمى على الافات ما قبل السرطانية الفموية فى عينة من المجتمع المصرى
Ghada Nabil Mohamed Assar ; Supervised Fat'heya Mohamed Zahran , Basma Abdelalim Zakaria , Aliaa Nabil Elmeshed
- Cairo : Ghada Nabil Mohamed Assar , 2020
- 159 P . : charts , facsmilies ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology
Aim: The aim of this randomized clinical trial was to test the ability of orally administered Thymoquinone to inhibit OPMDs oral leukoplakia progression into frank malignancy through modulation of molecular cancer biomarkers in patients with potentially malignant oral leukoplakia. Methodology: 48 patients with oral leukoplakia were randomly allocated to three groups; Nigella sativa 10mg, Nigella sativa 5mg and placebo groups. The treatment was administered in the form of a buccal tablet for three months. The outcomes assessed were clinical improvement, medication satisfaction and molecular biomarkers ki67 and caspase3. Results: There was a statistically significant decrease in lesion size in both the Nigella sativa groups in comparison to the placebo group. There was a statistically significant decrease ki-67 size in both the Nigella sativa groups in comparison to the placebo group. There was a statistically significant increase in caspase-3 in both the Nigella sativa groups in comparison to the placebo group Conclusion: Thymoquinone in Nigella Sativa is a promising chemopreventive agent that can be used in management of potentially malignant disorders
Placebo The cancer chemopreventive Thymoquinone compared