02982cam a2200265 a 4500003000900000005001700009008004100026040002800067041000800095100003400103245019100137246013900328260005300467300004300520502009900563520182700662530002202489653002202511653001302533653001502546700003802561700004002599700004402639856003302683EG-GiCUC20250223032753.0210626s2021    ua dh  f m    000 0 eng d  aEG-GiCUCbengcEG-GiCUC0 aeng0 aAli Elsayed Abdelgayed Hetiba10aFactors predicting surgical outcome of thymectomy in myasthenia gravis / cAli Elsayed Abdelgayed Hetiba ; Supervised Ehab Mohamed Elshihy , Tarek Ahmed Abbas Mohsen , Alaa Mohammed Omar15aالعوامل المؤثره علي نتائج استئصال الغده التيموسيه فى مرضى وهن العضلات  aCairo : bAli Elsayed Abdelgayed Hetiba , c2021  a79 P. : bcharts , facimiles ; c25cm   aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Cardiothoracic Surgery  aBackground: Myasthenia gravis (MG) is a disease affecting the neuromuscular junction and manifests as muscular weakness and fatigability. Thymectomy may benefit patients with MG.This operation can be performed through several different approaches. Many studies tried to analyze all factors could affect the outcome after thymectomy to identify which group of patients will benefit from surgery.Patient and methods: one hundred  patients underwent  thymectomy  for  myasthenia  gravis  in  the  period  between  June 2019 and November 2020 in Kasr Alainy hospitals were recruited to this study to evaluate predictors of outcome after thymectomy in the management of non thymomatous myasthenia gravis. Preoperative assessment included age, gender, co morbidities, MGFA classification, medication, plasmaphresis, also all patients performed CT chest, EMG and AChR Ab titre. Thymectomy was performed either by transsternal or VATS approach with documentation of the extent of resection; primary outcome was assessment of improvement by MGFA classification and need for medication.Secondary outcome was postoperative complications. Results: Complete stable remission was achieved in 5 patients, clinical and pharmacological improvements were achieved in 71 patients, 21 patients didn{u2019}t improve and only 3 patients worsen after surgery.Improvement rates in early onset of MG, patients didn{u2019}t have preoperative comorbidities and patients to whom extended thymectomy was performed were 79.3%, 77.3 % and 87.3% respectively. Also patients in whom postoperative AChR Ab decreased obviously had significant higher improvement rate. Although severely symptomatic patients had worse outcome, the correlation between preoperative MGFA classification and postoperative outcome was statistically insignificant (p value = 0.07)  aIssued also as CD 4aMyasthenia gravis 4aOutcome  4aThymecomy 0 aAlaa Mohammed Omar , eSupervisor0 aEhab Mohamed Elshihy , eSupervisor0 aTarek Ahmed Abbas Mohsen , eSupervisor  uhttp://172.23.153.220/th.pdf