02451cam a2200265 a 4500003000900000005001700009008004100026040002800067041000800095100003700103245021100140246013100351260005600482300004500538502009800583520128400681530002201965653001301987653001702000653001402017700004302031700004002074700003802114856003302152EG-GiCUC20250223032800.0210808s2021    ua dh  f m    000 0 eng d  aEG-GiCUCbengcEG-GiCUC0 aeng0 aHebatullah Effat Abdelaziz Elewa10aModulation of chemotherapeutic induced resistance in hepatocellular carcinoma cell lines / cHebatullah Effat Abdelaziz Elewa ; Supervised Motawa E. Elhusseiny , Sabry K. Shaarawy , Abdelhady A. Abdelwahab 15aتقليل المقاوم الناجته عن العلاج الكيميائى فى خلايا السرطان الكبديه   aCairo : bHebatullah Effat Abdelaziz Elewa , c2021  a176 P. : bcharts , facsimiles ; c25cm   aThesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology   aIIntroduction: Hepatocellular carcinoma (HCC) represents the sixth common cancer and the third leading cause of cancer-related mortality worldwide. It is more prevalent in males than in females. In Egypt, HCC constitutes a noteworthy widespread health problem, as it is accountable for 27.3% and 14.3% of all cancers in males and females respectively.The treatment options for HCC are limited and rely on patient stage. Doxorubicin drug-eluting bead transcatheter chemoembolization (TACE), a standard of care for patients particularly in the middle or advanced stage HCC is one of the vitally important approach and more promising evolutions in HCC treatment and used to diminish tumor load. Doxorubicin (Dox) is one of the most advantageous agents frequently used drugs in TACE, it has been shown that Dox can persue drug resistance resulting in poor patient prognosis and survival. MicroRNAs (MiRNAs), characterized as short, non-coding RNAs consisting of 18{u2013}25 nucleotides, were mentioned as powerful regulators of target mRNAs and make fine-scale adjustments to protein outputs. MiRNAs have been a recent focus in attempts to understand the mechanisms of Abstract 2 chemotherapy resistance particularly examining their ability to modulate known mechanisms of resistance  aIssued also as CD 4aDEB-TACE 4aDoxorubicin  4aMicroRNA 0 aAbdelhady A. Abdelwahab , eSupervisor0 aMotawa E. Elhusseiny , eSupervisor0 aSabry K. Shaarawy  , eSupervisor  uhttp://172.23.153.220/th.pdf