Mai Mohamed Elsayed Lotfy creator Abdelrahman Nabawy Zekri Supervisor Amany Abdelhhameed Aboubakr Supervisor Zeinab Korany M. Hassan Supervisor text theses ua Cairo Mai Mohamed Elsayed Lotfy 2021 monographic eng

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138 P. : charts , facsimiles ; 25cm detected pathogenic variants (PVs) and likely pathogenic variants (LPVs). These genes were found to be involved in DNA repair mechanisms and WNT/Ý-catenin signalling pathways that will ultimately lead to cancer development. Also, it was revealed that 27.2% of the tissue-derived PVs/LPVs could be detected in ctDNAs, and 35.7% of ctDNA-derived PVs/LPVs could be found in paired tissues. The overall concordance rates for all of the identified somatic variants, PVs/LPVs only and genes carrying PVs/LPVs between both assays across all patients are 85.48%, 82.46% and 76.10%, respectively. According to their Cohen{u2019}s Kappa values, they have a statistically significant slight to fair agreement in both biopsies. While, the positive concordance rates for all of the identified somatic variants, PVs/LPVs only and the genes carrying PVs/LPVs in both assays across all patients are 28.77%, 7.79% and 11.56%, respectively. The level of agreement between the 2 assays -confined to the presence of concordant variants only- was represented by the negative values of Cohen{u2019}s Kappa which implies a statistically significant disagreement between the two platforms specialized Mai Mohamed Elsayed Lotfy ; Supervised Abd Elrahman N. Zekri , Amany Abd Elhameed Aboubakr , Zeinab Korany M. Hassan Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology Issued also as CD Breast cancer patients Circulating tumor DNA http://172.23.153.220/th.pdf http://172.23.153.220/th.pdf EG-GiCUC 210913 20250223032814.0 eng