02894cam a2200337 a 4500 EG-GiCUC 20250223032911.0 220110s2021 ua dh f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.08.09.M.Sc.2021.Mo.P Mohamed Ahmed Mahmoud Salem Possible modulatory effect of tadalafil and bergapten on experimentally induced cognitive impairment in mice / Mohamed Ahmed Mahmoud Salem ; Supervised Nesrine Salah Eldine Elsayed , Suzan Mohamed Mansour تأثير فاعلية التطبيع المحتمل لعقارى التادالافيل والبيرجابتين لاعتلال الادراك المستحدث تجريبيا فى الفئران Cairo : Mohamed Ahmed Mahmoud Salem , 2021 139 P . : charts , facsmilies ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Toxicology and Biochemistry Sporadic Alzheimer{u2019}s disease (SAD) is a slowly progressive neurodegenerative disorder characterized by deposition of amyloid beta (AÝ) plaques, tau protein aggregation, impaired insulin signaling, and neuroinflammation. This study aimed to investigate the neuroprotective potential of tadalafil (TAD) and bergapten (BG) in SAD-induced cognitive impairment in mice. SAD was induced by a single intracerebroventricular injection of streptozotocin (STZ) (3 mg/kg). TAD or BG was administered intraperitoneally at doses of 20 and 25 mg/kg, respectively, 5 hours after STZ injection for 21 consecutive days. TAD and BG conceivably attenuated STZ-induced hippocampal insult, preserved neuronal integrity, and improved cognitive function in the Morris water maze and object recognition tests paralleled by reduced AÝ expression and phosphorylation of tau. Moreover, TAD and BG enhanced the protein expression of pAkt, pGSK-3Ý, beclin-1, and methylated protein phosphatase 2A (PP2A) and cyclin D1 gene expression and raised brain-derived neurotrophic factor immunoreactivity. In addition, both drugs boosted the hippocampal levels of cyclic guanosine monophosphate (cGMP), protein kinase G (PKG), WNT3A, and adenosine monophosphate-activated protein kinase coupled by reduced protein expression of Ý-catenin and mammalian target of rapamycin (mTOR). TAD and BG also halted neuroinflammation as evidenced by reduced IL-23 and IL-27 levels and NF-mB protein expression Issued also as CD Bergapten Sporadic Alzheimer{u2019}s disease Tadalafil Nesrine Salah Eldine Elsayed , Supervisor Suzan Mohamed Mansour , Supervisor http://172.23.153.220/th.pdf Amira Cataloger Nazla Revisor ddc TH 83935 83935 ddc 0 CUCL cl210 2024-02-11 Cai01.08.09.M.Sc.2021.Mo.P 01010110085249000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.08.09.M.Sc.2021.Mo.P 01020110085249000 2023-09-22 00:00:00 85249.CD CD