02387cam a2200349 a 4500 EG-GiCUC 20250223032912.0 220115s2021 ua dh f m 000 0 eng d EG-GiCUC eng EG-GiCUC eng Deposite M.Sc Cai01.08.03.M.Sc.2021.Ma.A Manar Mohamed Mohamed Elhassan Application of different analytical techniquesfor the determination of some antidiabetics / Manar Mohamed Mohamed Elhassan ; Supervised Maha Abdelmonem Hegazy , Shereen Hassib , Amr Mahmoud Bekhet تطبيق تقنيات تحليلية مختلفة لتعيين بعض الأدوية المضادة لداء السكرى Cairo : Manar Mohamed Mohamed Elhassan , 2021 232 P. : charts , facsimiles ; 25cm Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry This work is concerned with the determination of some antidiabetic agents of three different classes. Ipragliflozin, Ertugliflozin and Dapagliflozin were selected from the class of Sodium-Glucose cotransporter-II inhibitors. Sitagliptin and Saxagliptin were chosen from the class of dipeptidyl peptidase-IV inhibitors and Metformin was selected from the class of biguanides. The selected drugs have been analyzed using electrochemical, chromatographic and spectrophotometric methods. First, electrochemical methods were employed for the analysis of Ipragliflozin and Sitagliptin. Ipragliflozin was determined using differential pulse voltammetry that depends on the oxidation of sulfur atom. The method was applied by scanning the potential over range of 0 to 2.8 V by using a scan rate of 10 mV/s versus the reference electrode Ag/Ag+ in non-aqueous medium while using glassy carbon electrode as an indicator electrode.The method was then successfully applied for the analysis of Ipragliflozin in spiked human plasma Issued also as CD Dapagliflozin Ertugliflozin Ipragliflozin Amr Mahmoud Bekhet , Supervisor Maha Abdelmonem Hegazy , Supervisor Shereen Hassib , Supervisor http://172.23.153.220/th.pdf Nazla Revisor Shimaa Cataloger ddc TH 83978 83978 ddc 0 CUCL cl210 2024-02-11 Cai01.08.03.M.Sc.2021.Ma.A 01010110085237000 2023-09-22 00:00:00 TH ddc 0 CUCL cl2u8 2024-02-11 Cai01.08.03.M.Sc.2021.Ma.A 01020110085237000 2023-09-22 00:00:00 85237.CD CD