Mahmod Morad Ragab Mohammed creator preparation. Heba Mohammed Kamal Abdelhakeem thesis advisor. Ismail Abd Elshafy Abd Elhamid thesis advisor. Olfat Gamil Shaker thesis advisor. text theses ua 2021 monographic eng ara 84 Pages : charts , facsimiles ; 25cm+ CD Background: Colorectal cancer (CRC) is a complex disease that develops as a consequence of both genetic and environmental risk factors. Diet, smoking and drinking habits are among environmental factors frequently associated with CRC risk. Aim of work:The present study aims to conduct a clinical biochemical study that aids in the investigation of some non-coding RNA expressions and polymorphisms (including long non-coding RNAs and miRNAs) namely, Plasmacytoma Variant Translocation-1 (PVT-1) and miR-186 in an attempt to provide new noninvasive diagnostic biomarkers for CRC of the Egyptian patients. Patients and methods: Eighty CRC studies and thirty healthy controls were included. Laboratory and pathological investigations were assessed. Serum miR-186 and long non-coding PVT-1 was measured as well as genotype for PVT-1 rs13255292. Results: The CRC patients had a mean age of 50.91±12.0. The mean serum miR-186 level in CRC patients (1.38±0.21) was significantly higher than in the control (0.93±0.1) (p=0.0001). The PVT-1 level in CRC patients was (5.91±0.25) significantly higher than control (1.1±0.2) (p=0.001). The PVT-1/ rs13255292 genotype CT was significantly higher compared to the control group. The T allele was highly significant with a p-value of 0.008 in the CRC patient group with respect to the control. Conclusion: miR-186, long noncoding PVT-1 as well as PVT-1 the T allele may be considered as genetic markers for CRC susceptibility specialized Mahmod Morad Ragab Mohammed ; Supervised Prof.Dr. Ismail Abdelshafy Abdelhamid , Prof.Dr.Heba Mohammed Kamal Abdelhakeem , Prof.Dr.Olfat Gamil Shaker. Thesis ( Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry Bibliography: pages 115-137. Issued also as CD Text in English and abstract in Arabic & English. Biochemistry Colorectal Cancer (CRC) Long non-coding RNAs (lncRNAs) MicroRNAs (miRNAs) 540 EG-GiCUC 220306 20260516114337.0 eng