TY  - BOOK
AU  - Mahmod Morad Ragab Mohammed,
AU  - Heba Mohammed Kamal Abdelhakeem 
AU  - Ismail Abd Elshafy Abd Elhamid 
AU  - Olfat Gamil Shaker 
TI  - Expression and polymorphism of long non-coding RNAs in colorectal cancer / 
U1  - 540 
PY  - 2021///
KW  - Biochemistry
KW  - Colorectal Cancer (CRC)
KW  - Long non-coding RNAs (lncRNAs)
KW  - MicroRNAs (miRNAs)
N1  - Thesis ( Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry; Bibliography: pages 115-137; Issued also as CD
N2  - Background: Colorectal cancer (CRC) is a complex disease that develops as a consequence of both genetic and environmental risk factors. Diet, smoking and drinking habits are among environmental factors frequently associated with CRC risk. Aim of work:The present study aims to conduct a clinical biochemical study that aids in the investigation of some non-coding RNA expressions and polymorphisms (including long non-coding RNAs and miRNAs) namely, Plasmacytoma Variant Translocation-1 (PVT-1) and miR-186 in an attempt to provide new noninvasive diagnostic biomarkers for CRC of the Egyptian patients. Patients and methods: Eighty CRC studies and thirty healthy controls were included. Laboratory and pathological investigations were assessed. Serum miR-186 and long non-coding PVT-1 was measured as well as genotype for PVT-1 rs13255292. Results: The CRC patients had a mean age of 50.91±12.0. The mean serum miR-186 level in CRC patients (1.38±0.21) was significantly higher than in the control (0.93±0.1) (p=0.0001). The PVT-1 level in CRC patients was (5.91±0.25) significantly higher than control (1.1±0.2) (p=0.001). The PVT-1/ rs13255292 genotype CT was significantly higher compared to the control group. The T allele was highly significant with a p-value of 0.008 in the CRC patient group with respect to the control. Conclusion: miR-186, long noncoding PVT-1 as well as PVT-1 the T allele may be considered as genetic markers for CRC susceptibility
ER  -