Thesis (M.Sc.) - Cairo University - Faculty of Physical Therapy - Department of Physical Therapy for Internal Medicine

Chronic kidney disease (CKD) is the progressive deficiency of renal function for months and years and frequently present with elevation in markers of inflammation especially serum C-Reactive Protein (CRP) that may have a clinical prediction for risk of cardiovascular disease (CVD) which is the leading cause of morbidity and mortality in patients with CKD. Patients on maintenance hemodialysis usually have poor exercise capacity and are less physically active, which have been identified as independent risk factors of mortality. Aim the Study: This study was conducted to evaluate the effect of 2 months intradialytic aerobic exercise on (CRP) for patients with chronic kidney disease. Subjects and Methods: Forty hemodialysis patients of both sexes with chronic renal failure participated in the study, their age ranged from 55 to 65 years old and recruited randomly from hemodialysis unit of October 6 University hospital. They were randomly assigned into two groups (A&B). Study group (A) (17 males and 13 females) received 3 sessions per week for 2 months of intradialytic aerobic exercise while Control group (B) (6 males and 4 females) received only their medical treatment. All patients in both groups were assessed through serum CRP, Blood urea, creatinine lab tests and Borg rating of perceived exertion scale was used to assess functional activity before and after treatment. Results: Results showed that in the study group there was significant decrease in CRP, Urea 36.62%, 22.2% respectively and in the control group CRP, Urea decreased by 11.39%, 7.33% respectively. While creatinine decreased by 5.04% in the study group and by 7.33% in the control group, Borg scale scores increased by 48.43% significantly in the study group and increased by 2.88% in the control group

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