Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry

An efficient and convenient method for the synthesis of bis (4H-chromene-3-carbonitrile) derivatives. The synthetic pathway involves one pot, multi-component reaction of bis- aldehydes, malononitrile, and dimedone in the presence of a catalytic amount of piperidine. A stepwise approach for the synthesis of the target compounds was also investigated. Bis (2- benzylidene-1H-indene)-1,3-(2H)-dione derivatives were obtained as the main products as a result of reaction of the bis(arylidenemalononitriles) with indandione. The anti-influenza H5N1 virus activities of the newly prepared bis-chromene derivatives are also investigated. An efficient and convenient route for the synthesis of novel bis dihydropyrano[3,2- c]chromenes is reported. The synthetic pathway involves one pot, multi-component reaction of bis-aldehydes, malononitrile, and 4-hydroxycoumarin in the presence of pyridine or acetic acid in the presence of sodium acetate. A stepwise approach for the synthesis of the target compounds was also investigated. The structures of all compounds are confirmed based on the different spectral tools

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