Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine

Helicobacter pylori has been clearly recognized as an important cause of gastritis and cases of peptic ulcer. Because these episodes present a life - threatening complication in patients with bleeding disorders, we investigated the prevalence of H. pylori infection in patients with hemophilia A, B and von willebrand disease and assessed the risk of gastrointestinal bleeding associated with this infection. 40 male patients above 12 years with hemophilia A, B or von willebrand disease {u200E}and 20 controls were included. Patients and control were divided into two groups according to occult blood test result; either negative or positive. 70 % of patients were H. pylori positive, of whom 5 patients tested positive for occult blood, while 60 % of control subjects were H. pylori positive, of whom only one tested positive for occult blood meaning that the odds ratio for developing H. pylori related GI bleeding in patients with bleeding disorder is 2.3913, confidence Interval: 0.2485 to 23.0104, Z statistic: 0.755, significance level: P = 0.4504

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