5- lipoxygenase pathway genes polymorphisms in Egyptian patients with bronchial asthma / Maha Hosni Ibraheem ; Supervised Amal Abdelwahab Mohammed , Hanan Ali Madani , Wafaa Ashour

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Maha Hosni Ibraheem

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TextLanguage: English Publication details: Cairo : Maha Hosni Ibraheem , 2014Description: 132 P. : charts ; 25cmOther title:

التنوع الشكلى لمسار جين ال٥ مؤكسد الدهون فى مرضى الربو الشعبى المصريين [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Bronchial asthma (BA) is a chronic disorder of the airways. 5- lipoxygenase (5 - LO) play an essential role in the biosynthesis of leukotrienes that induce proinflammatory actions. The aim of this study was to determine the 5- lipoxygenase (5 - LO) pathway polymorphisms in asthmatic patients and to understand their role in the pathophysiology of BA. 50 asthmatic patients and 30 controls were included in this study. 3 genes were studied (LTC4S - 444A / C using polymerase chain reaction / Restriction fragment length polymorphism (PCR / RFLP), ALOX5 - 176 / - 147 using fragment length analysis and ALOX5AP - 169 / - 146 by real time PCR). There was statistically significant increase in the mutant genotype of ALOX5AP - 169 - 146 gene among the patients group compared to the control group (P = 0.004) with 4.5 times risk of bronchial asthma among those carrying the mutant {u2018}357{u2019} allele of Alox5AP{u2013}169{u2013}146 gene OR = 4.529, 95% CI = 1.7 - 12.018, P < 0.001

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.07.Ph.D.2014.Ma.F (Browse shelf(Opens below))		Not for loan	01010110064359000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.07.Ph.D.2014.Ma.F (Browse shelf(Opens below))	64359.CD	Not for loan	01020110064359000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Bronchial asthma (BA) is a chronic disorder of the airways. 5- lipoxygenase (5 - LO) play an essential role in the biosynthesis of leukotrienes that induce proinflammatory actions. The aim of this study was to determine the 5- lipoxygenase (5 - LO) pathway polymorphisms in asthmatic patients and to understand their role in the pathophysiology of BA. 50 asthmatic patients and 30 controls were included in this study. 3 genes were studied (LTC4S - 444A / C using polymerase chain reaction / Restriction fragment length polymorphism (PCR / RFLP), ALOX5 - 176 / - 147 using fragment length analysis and ALOX5AP - 169 / - 146 by real time PCR). There was statistically significant increase in the mutant genotype of ALOX5AP - 169 - 146 gene among the patients group compared to the control group (P = 0.004) with 4.5 times risk of bronchial asthma among those carrying the mutant {u2018}357{u2019} allele of Alox5AP{u2013}169{u2013}146 gene OR = 4.529, 95% CI = 1.7 - 12.018, P < 0.001

Issued also as CD

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