Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Analytical Chemistry

Potentiometric electrodes were developed for the rapid determination of proguanil hydrochloride and galantamine hydrobromide in pure samples, pharmaceutical preparations and spiked serum and urine samples using PVC membrane, screen printed (SPE), coated wired (CWE), carbon paste (CPE) and modified carbon paste (MCPE) electrodes based on the ion-exchanger of proguanil with phosphotungestic acid (Pr-PT) and galantamine with ammonium renickat (Ga-Rt) as a chemical modifiers. The prepared electrodes exhibited high proguanil and galantamine selectivity in relation to several inorganic ions and sugars and they could be successfully utilized for its determination in pure solutions, pharmaceutical preparations and serum and urine samples using the direct potentiometry and standard addition methods with very good recovery values

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