Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology

Background: Periodontitis is an inflammatory disease of gingival and bone tissues. Left untreated it can lead to significant morbidity. It has been suggested that periodontitis may be associated with various oral and non-oral ({u2018}systemic{u2019}) conditions including coronary artery disease (CAD) by contributing to systemic inflammation. Oral inflammation (oral inflammatory load (OIL) can be quantified by measuring the levels of oral poly morph neutrophil (oPMN) in patients using a simple oral rinse assay for oPMN. Methods: We prospectively recruited consecutive eligible patients with stable angina and ACS patients undergoing angiography at our cardiac tertiary centre. Two sets of oral rinse samples were collected pre and post procedure. Tertiles of oPMN were correlated with tertiles of the SYNTAX score by spearman{u2019}s rho to establish correlation. In addition a receiver operating curve (ROC) curve was plotted to assess correlation between values of oPMN and a re-coded binary SYNTAX score ((0=low and 1{u2265}intermediate severity CAD). Results: Of the 137 patients recruited 32.8% (n=45) were female and 34.3% (n=47). The mean SYNTAX score was 7.4 ± 8.5. There was no correlation between the tertiles of oPMN and SYNTAX score when analysed by Spearman{u2019}s rho for all patients (p=ns). Correlation between high/intermediate SYNTAX score and oPMN values was also negative (p=ns). Conclusion: No correlation was demonstrated in this small prospective study looking at the relationship between OIL and severity of CAD. The mean SYNTAX score was low and patients with intermediate/high scores accounted for <10% of the patient cohort. Larger studies including patients with higher SYNTAX scores may demonstrate a different outcome. To the best of our knowledge, this is the first prospective paper that has attempted to demonstrate correlation between OIL and CAD

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