Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Seeking a satisfactory cure of OA disease is still considered as an important issue to date, hoping to recover the original state of the affected joint as possible or even pause the degradation progress before massive complications take place. The current thesis gives an exhaustive description that briefly explains the OA disease via research and review articles with a focus on the pathophysiological point of view concerning the available treatment options and understanding the intervention gates of green biosynthesized AuNPs that provide a promising medical approach for OA treatment. Biochemical and histological results in addition to genetic ones that were explained in the research article boosted the profound influence of AuNPs on arthritic joints. The current research study has been conducted on a total of 56 mature female Sprague{u2013} Dawley rats (150-160 g, 3 months old) divided into eight groups (7 rats/ group) for assessment of the anti-inflammatory effect of biosynthesized nanogold on OA induced in rats with and without diacerein drug, and the experimental results revealed that: - AuNPs could be biosynthesized via "the green synthesis" manner using an aqueous extract of chenopodium murale leaves as an eco-friendly method for bioreduction of gold from Au3+ to Au0 by the polysaccharides and protein of the leaf extract which acting as a reducing agent or electron donor

Issued also as CD