Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

The objective of this work is to develop simple, accurate and precise methods for the determination of some pharmacologically active drugs either alone and in binary mixtures. These methods are required for quality control of these drugs in their bulk powder, dosage forms and in biological fluids. Drugs under investigation include: Dicyclomine Hydrochloride (antispasmodic), Tromantadine Hydrochloride (antiviral), Timolol Maleate (antiglaucoma) and Brimonidine Tartrate (antiglaucoma). The quantification of the studied drugs has been adopting a variety of analytical techniques. Voltammetric techniques are a powerful and versatile analytical technique that offers high sensitivity, accuracy, and precision as well as a large linear dynamic range, with relatively low-cost instrumentation. Owing to the development of advanced stripping and pulse techniques, voltammetric methods become highly competitive with other instrumental methods of analysis in terms of sensitivity and reliability. So, Stripping analysis was suggested as method for the determination of drugs at different electrodes and proposed oxidation mechanism is described. Potentiometry was suggested as the most widespread since the early 1930s, due to their simplicity, familiarity and cost. Potentiometric sensors make use of the development of an electrical potential at the electrode surface when it is placed in a solution containing ions which can be exchanged through the surface. The largest group among potentiometric sensors is represented by ion-selective electrodes (ISEs)

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