Dimeric adamantane analogs as inhibitors of viral M2 and p7 channels : Synthesis, molecular modeling and biological evaluation / Yasmine Magdy Abbas Elfawal Mandour ; Supervised Darius P. Zlotos , Frank M. Boeckler , Hans G. Breitinger
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TextLanguage: English Publication details: Cairo : Yasmine Magdy Abbas Elfawal Mandour , 2016Description: 204 Leaves : charts ; 30cmSubject(s): Online resources: Dissertation note: Thesis (Ph.D.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceulical Chemistry Summary: HCV represents a major health problem with about 170 million people infected worldwide. Among the difficulties in treating HCV is its high degree of genetic diversity with seven divergent genotypes identified each with many subtypes that respond differently to treatment. The HCV genome undergoes translation into eleven different structural and non-structural proteins. The non-structural proteins are responsible for viral replication and so represent important drug targets. However, direct-acting antivirals suffer from several setbacks and drugs targeting other HCV proteins may be useful for a more effective treatment
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Thesis
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قاعة الثقاقات الاجنبية - الدور الثالث | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.34.Ph.D.2016.Ya.D (Browse shelf(Opens below)) | Not for loan | 01010110072432000 |
Thesis (Ph.D.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceulical Chemistry
HCV represents a major health problem with about 170 million people infected worldwide. Among the difficulties in treating HCV is its high degree of genetic diversity with seven divergent genotypes identified each with many subtypes that respond differently to treatment. The HCV genome undergoes translation into eleven different structural and non-structural proteins. The non-structural proteins are responsible for viral replication and so represent important drug targets. However, direct-acting antivirals suffer from several setbacks and drugs targeting other HCV proteins may be useful for a more effective treatment
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