Thesis (Ph.D)-Cairo University, 2024.

Bibliography: pages 77-95.

Approximately 85% of stroke patients with aphasia recover from the aphasia within 3–6 months after onset; however, some may require additional time for recovery. Aim of work: To assess the effect of some demographics, clinical and neuroimaging variables on recovery of post stroke aphasia and to evaluate the effect of different therapeutic modalities (medical treatment, intravenous (IV) thrombolysis (recombinant tissue plasminogen activator (rtPA), mechanical thrombectomy) on language function among patients with ischemic stroke. Patients and Methods: This prospective cohort study included 100 right handed patients with post stroke language disorders. Patients were divided into 50 patients treated with medical therapy and 25 patients treated with IV thrombolysis and 25 patients treated with mechanical thrombectomy. Assessment of severity of stoke was done using National Institutes of Health Stroke Scale (NIHSS). Carotid duplex and echo were done. Computed tomography and/or magnetic resonance imaging were performed. Speech assessment tests (Kasr El Aini Arabic Aphasia test (KAAT) and Voice handicap index (VHI)) were done within 1 week followed within 3 and 6 months later. Results: Patients with small brain infarction had better mean scores of KAAT and VHI compared to those with large brain infarction also patients with dyslipidemia had significantly better KAAT and VHI mean scores compared to non-dyslipidemic patients. Moreover, patients with Small vessel disease had better KAAT and VHI mean scores compared to those with large vessel disease .Furthermore, nonsmokers had higher KAAT mean scores compared to smokers. Improvement of KAAT and VHI mean score from the onset of the disease to the follow up after 3 and 6 months in patients who received medical treatment,,IV thrombolysis and thrombectomy. There is no statistical significant difference between different methods of treatment (medical treatment, IV thrombolysis and thrombectomy.) as regards KAAT and VHI scores at onset of the disease, 3 months and 6 months later. Conclusion: Factors associated with good recovery of aphasia include absence of dyslipidemia, small infarction and small vessel disease. It seems that there is an improvement of speech mean scores with time after behavioral speech and language therapy (SLT), regardless method of treatment (medical treatment ,IV thrombolysis, thrombectomy).

صُممت هذه الدراسة الفوجية المرتقبة لتقييم تأثير بعض المتغيرات الديموغرافية والاكلينكيه التصويرية العصبية على التعافي من فقدان القدرة على الكلام بعد السكتة الدماغية وتقييم تأثير الطرق العلاجية المختلفة (العلاج بالعلاج الدوائي وانحلال الخثرة الوريدي، واستئصال الخثرة الميكانيكي) على الوظيفة اللغوية بين المرضى المصابين بالسكتة الدماغية الحاده.
شارك في هذه الدراسة مائة مريض يستخدمون اليد اليمني مصابين باضطرابات لغوية بعد السكتة الدماغية. تم تقسيم المرضى إلى 50 مريضًا مريضًا تم علاجهم بالعلاج الدوائي و25 مريضًا تم علاجهم بانحلال الخثرة الوريدي و25 مريضًا تم علاجهم باستئصال الخثرة الميكانيكي.

Issues also as CD.

Text in English and abstract in Arabic & English.