Thesis (M.Sc)-Cairo University, 2025.

Bibliography: pages 69-83.

Background: Sleeve gastrectomy is a widely performed bariatric procedure, but
postoperative staple line leakage remains a significant complication, leading to
increased morbidity and healthcare costs. Various techniques have been
explored to reinforce the staple line, yet an optimal solution remains elusive.
nebulized cyanoacrylate glue , a novel surgical adhesive, has shown promise in
preliminary studies for its ability to enhance tissue sealing and reduce
complications.
Objectives: This study aims to evaluate the effectiveness of nebulized
cyanoacrylate glue in reinforcing the staple line during sleeve gastrectomy and
its impact on reducing postoperative leakage rates. Additionally, it seeks to
assess its influence on operative time, length of hospital stay, and overall
postoperative complications.
Methods: A prospective Randomized Controlled Clinical Trial was conducted
involving 70 patients undergoing sleeve gastrectomy. Participants were divided
into two equal groups: one without staple line reinforcement and the other
utilizing nebulized cyanoacrylate glue in reinforcement of staple line. Data were
collected on intraoperative parameters, postoperative leakage rates, hospital stay
duration, and other complications. Statistical analysis was performed to compare
outcomes between the two groups.
Results: The nebulized cyanoacrylate glue group demonstrated a statistically
no significant reduction in postoperative staple line leakage rates compared to
the Non reinforcement group. The findings suggest that the choice between two
methods does not significantly impact the incidence of leakage.
Conclusion: No statistically difference in post-operative leakage rate between
the glue-reinforced and non-reinforced groups. Both groups have similar
outcomes in terms of bleeding, hospital stay duration, and readmission rates.
These findings suggest that glue reinforcement of staple line does not provide a
significant advantage in preventing staple line leakage over non-reinforcement.

تعد جراحة تكميم المعدة من اقصر عمليات السمنه انتشارا. المضاعفات ما بعد عمليات السمنة ومنها جراحة تكميم المعدة تؤثر بشكل كبير على صحة المريض وكذلك عبئا على المنظومة الصحية. وسائل مختلفة تم اقتراحها لتقوية حواف المعدة المكممة لتقليل التسريب ما بعد الجراحة ولكن ما زالت هذه الوسائل تحت الدراسة حتى يتم الوصول لحل مناسب لتقليل التسريب. يعتبر الصمغ الجراحى من احدى هذه الوسائل التى يتم دراستها الان بعد ما اظهر فاعليته على بعض الجروح. وتهدف هذه الدراسة الى معرفة مدى تأثير الضمغ الجراحى على تقليل حالات المعدة المقننة وتوضح مدى تأثيره على تقليل نسبة التسريب بعد عمليات التكميم

Issues also as CD.

Text in English and abstract in Arabic & English.