Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy

The Crassulaceae (stonecrop family) is a very diverse group, and plants range from tiny insignificant annual herbs to perennial shrubs and trees. Many of the species have attractive flowers. The entire family consists of 33 genera and 23 hybrid genera with a total of 1410 species and 305 intraspecific taxa. The genus Crassulaincludes around 200 species of succulent plants, ranging in size from less than one inch in height to 6 foot shrubs. Throughout the last period, researchers gave an attention for the compounds isolated from cactus plants (Ornamental Plants). But, there was no much work concerning the chemical composition or biological activity of genus Crassulaor species tetragonanor ovata. Aim of the work: a)- to investigate DNA fingerprint of Crassulatetragona and Crassulaovata, b) -Preliminary phytochemical screening to identify the nature of the active constituents.C)-Investigation of the lipid content of the two plants. D)-Quantitative estimation of total flavonoid, phenolics and triterpenes contents. E)- Isolation, identification and structure elucidation of the major isolated constituents from the methylene chloride fractions. F)-LC/MS/MS of n-Butanol fractions of both plants.G)- Determination of the plant safety (the acute toxicity study). H)- Determination of the anti-hyperglycemic activity of the total ethanolic extracts of the aerial parts of both plants. I)- Determination of the anti-hyperlipidemic activity of the total ethanolic extracts of the aerial parts of both plants. I)-A study of the antioxidant activity of the total ethanolic extracts, methylene chloride and n-butanol fractions of both plants. J)-Determination of anti-microbial activity of the ethanolic extracts, methylene chloride and n-butanol fractions of both plants

Issued also as CD