Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Ophthalmology

Purpose: To evaluate, with fundus perimetry, the peripapillary differential light threshold (DLT) in primary open angle glaucoma (POAG) Patients and glaucoma suspects(GS) and correlate it with peripapillary retinal nerve fiber layer (RNFL) thickness by using spectral-domain optical coherence tomography (SDOCT). Methods: This study was an observational case control study including a total of (45 eyes) classified into 3 groups: group1: Primary open angle glaucoma patients with mild to moderate glaucoma (15 eyes), glaucoma suspects (15 eyes, normal controls (15 eyes). All study subjects underwent complete ophthalmic examinations, peripapillary microperimetry and OCT using the same device optos-OCT SLO , then statistical analysis was done for all the results. Results: In this study, it is found that functional parameters (DLT) significantly differentiated between controls and glaucoma cases and between glaucoma cases and suspect also between controls and suspects (P value <0,000), while structural parameters (NFLT) significantly differentiated between controls from cases, and suspects from cases (P value <0,000) but could not differentiate controls from suspects (p value 0,749). Conclusions: Whereas OCT measurement of RNFL thickness is currently used for the detection of early RNFL morphological damage in GS and glaucomatous eyes, topographically related functional information from the same areas may be useful, particularly in eyes without standard visual field loss

Issued also as CD