Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine

Background: The cardiovascular system is one of the most important targets on which thyroid hormones act (132), thyroid hormone has a major role in the cardiovascu»lar system function and cardiac hemodynamics (133, 134). Serum thyroid hormone levels have been described in several systemic non-thyroidal illnesses, among them acute heart diseases. A slight change in thyroid status affects ventricular func»tion, serum cholesterol levels, heart rate, heart rhythm, and increases risk of coronary artery disease and cardio»vascular mortality (149). Nevertheless, the relation between anomalous thyroid function and cardiovascular effects remains indistinct (150). Objectives: The aim of our study is toevaluate the prevalence of thyroid dysfunction in patients with acute myocardial infarction and to study the impact of these dysfunctions on in-hospital morbidity and mortality among those subjects. Patients and Methods: This study was conducted on one hundred critically ill patients admitted to the critical care department with the diagnosis of acute myocardial infarction in the period from April 2017 to January 2019. All patients were subjected to the following:Full history taking, clinical examination, ECG, and routine laboratory investigations.Echocardiography: to evaluate wall motion score index (WMSI), left ventricular ejection fraction (LVEF %), the myocardial performance index (MPI) and to detect any ischemic complications

Issued also as CD