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040			_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda
041	0		_aeng _beng _bara
049			_aDeposit
082			_a571.9
092			_a571.9 _221
097			_aPh.D
099			_aCai01.10.05.Ph.D.2021.Sh.C
100			_aShereen Youssef Elsayed Abd Elmotaleb Youssef, _epreparation.
245			_aClinicopathological Studies on the Effect of Bone MarrowStem Cells on Experimental Diabetic Rats / _cby Shereen Youssef Elsayed Abd Elmotaleb Youssef; Prof.Dr. Safaa Yassin Sayed Ahmed, Prof.Dr.Shaymaa Ismaeil Salem.
246			_aدراسات باثولوجية إكلينيكية على تأثير الخلايا الجذعية النخاعية على الفئران المصابة تجريبيا بالداء السكرى
264		0	_c2021.
300			_a79 p. : _billustrations _c25cm _eCD.
336			_2rda content _atext
337			_2rdamedia _aUnmediated
338			_2rdacarrier _avolume
502			_aThesis (Ph.D)-Cairo Univsersity,2021
504			_aBibliography: P. 68-92
520		3	_a Diabetes mellitus is a group of metabolic diseases -multi-systemic disorder- characterized by hyperglycemia resulting from defects in insulin secretion. The therapeutic treatment with bone marrow mesenchymal stem cells “BM-MSCs” has a promising value in the management of kidney, liver and pancreatic degeneration. Fifty male rats were used in this experiment; 5 rats as a source of BM-MSCs, 5 rats (STZ-diabetic) as the cell tracking and the other 40 rats were randomly assigned into 4 equal groups; normal control (I), stem cell (II), untreated diabetic (III), and treated diabetic (BM-MSCs) (IV). To induce DM, rats were intraperitoneally injected single dose of streptozotocin (STZ) (55 mg/kg BW). The BM-MSCs were collected from 10 rats’ bone marrow, cultured, characterized using flow cytometry analysis and labeled with Qtracker 655 cell labeling. BM-MSCs were transplanted in treated diabetic at the 7th day of STZ injection. Rats were euthanized 4 weeks after STZ injection. Blood samples were collected at the end of experiment (4th week of BM-MSCs transplantation). The pancreas, kidney and liver tissues were collected. Hemogram, biochemical parameters (liver & Kidney function tests), insulin gene expression and histopathological examination of pancreas, liver and kidney, were performed for all experimental groups. Untreated diabetic group showed significant disturbances in liver, kidney and pancreatic functions with excessive production of inflammatory cytokine (TNF-α) in kidney tissues and increased oxidative stress in liver tissues. The BM-MSCs treated diabetic group showed significant improvement in organs functions, insulin gene expression as well as hematological and histopathological examinations. In conclusion, treatment with BM-MSCs in diabetic rats improved the diabetic profile and ameliorated some of its complications.
530			_aIssues also as CD.
546			_aText in English and abstract in Arabic & English.
650			_aDiabetes mellitus
653			_apathology
700			_aSafaa Yassin Sayed Ahmed _ethesis advisor.
700			_aShaymaa Ismaeil Salem _ethesis advisor.
900			_b01-01-2021 _cSafaa Yassin Sayed Ahmed _cShaymaa Ismaeil Salem _UCairo University _FFaculty of Veterinary Medicine _DDepartment of Clinical Pathology
905			_aShimaa
942			_cTH _2ddc
999			_c163726