000			04091namaa22004331i 4500
003			OSt
005			20250223033307.0
008			241001s2023 |||a|||fr|m|| 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda
041	0		_aeng _beng _bara
049			_aDeposit
082	0	4	_a618.92
092			_a618.92 _221
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2023.Mo.A
100	0		_aMohammed Sayed Ebraheem Awaad, _epreparation.
245	1	0	_aAssociation of Superoxide Dismutase (SOD2 Val16Ala) genetic polymorphism with Cardiac Problems in Egyptian Pediatric Beta-Thalassemia major patients / _cby Mohammed Sayed Ebraheem Awaad ; Supervised by Prof. Dr. Mona Mohamed Hamdy Mahmoud, Prof. Dr. Iman Abd El-Mohsen Shaheen, Prof. Dr. Rasha Abdel-Raouf Abdel-Aziz
246	1	5	_aارتباط اشكال التعدد الوراثي لجين الديسموتيز فائق الاكسده (Ala16 Val SOD2) بمشاكل القلب في الاطفال مرضي انيميا البحر المتوسط الكبري المصريين /
264		0	_c2023.
300			_a140 pages : _billustrations ; _c25 cm. + _eCD.
336			_atext _2rda content
337			_aUnmediated _2rdamedia
338			_avolume _2rdacarrier
502			_aThesis (M.Sc.)-Cairo University, 2023.
504			_aBibliography: pages 118-140.
520			_aβ-Thalassemia major continues to be a major cause of morbidity and mortality with improving outcome due to advances in researches and treatments. This study was designed to detect the association of the antioxidant enzyme Super Oxide Dismutase 2 (SOD2) Val16Ala (rs4880) genetic polymorphism with cardiac problems in Egyptian children with β-Thalassemia major. Results: A total number of 60 pediatric patients with β-Thalassemia major with age ranged from 8-18 years were genotyped for the SOD2 Val16Ala (rs4880) polymorphism. Also, Echocardiography study was done to them to assess cardiac problems related to contractility and chambers size. LVEDD: was high in 10 (38.5%) patients, 8 (26.7%) patients and 2 (50.0%) patients with means 46.12 ± 4.55, 46.97±5.77, 48.50 ±7.51 respectively for AA, AG and GG groups, LVESD: was high in 10 (38.5%) patients, 8 (26.7%) patients and 2 (50.0%) patients with means of 30.69±4.69, 29.40±6.53, 32.0±7.16 respectively for AA, AG and GG groups, IVSD: was high in 10 (38.5%) patients, 10 (33.3%) patients and 3 (75%) patients respectively with means 0.83±0.19, 0.84±0.23, 0.98±0.17 for AA, AG and GG groups, LVPWT: was high in 17 (65.4%) patients, 16 (53.3%) patients and 4 (100%) patients respectively with means 0.83±0.19, 0.80 ± 0.15, 1.09±0.25 for AA, AG and GG groups. Regarding cardiac function: EF was low only in 1 (3.8%) patient in AA group, E/A ratio: was low only in 1 (25%) patient in GG group. Results showed no association between SOD2 Val16Ala (rs4880) genetic polymorphism and cardiac problems with a P-value > 0.05.
520			_aأجريت هذه الدراسة على 120 من الاطفال بقسم امراض الدم بمستشفى أبو الريش للاطفال بجامعة القاهرة اجريت الدراسة لمعرفة العلاقه بين الطفرة الجينية لانزيم الدسموتيز فائق الأكسدة ومشاكل القلب للاطفال المصابون بمرض أنيميا البحر المتوسط الكبرى المصريين.
530			_aIssued also as CD
546			_aText in English and abstract in Arabic & English.
650		7	_aPediatrics _2qrmak
653		0	_aThalassemia _aSOD2 _aCardiac Problems
700	0		_aMona Mohamed Hamdy Mahmoud _ethesis advisor.
700	0		_aIman Abd El-Mohsen Shaheen _ethesis advisor.
700	0		_aRasha Abdel-Raouf Abdel-Aziz _ethesis advisor.
900			_b01-01-2023 _cMona Mohamed Hamdy Mahmoud _cIman Abd El-Mohsen Shaheen _cRasha Abdel-Raouf Abdel-Aziz _dShahira Kamal _dAmira Abdel Moneim _UCairo University _FFaculty of Medicine _DDepartment of Pediatrics
905			_aEman _eHuda
942			_2ddc _cTH _e21 _n0
999			_c168196