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005			20250529112509.0
008			250521s2024 ua a|||fr|m|| 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda
041	0		_aeng _beng _bara
049			_aDeposit
082	0	4	_a616.01
092			_a616.01 _221
097			_aM.Sc
099			_aCai01.11.19.M.SC.2024.Es.I.
100	0		_aEsraa Kamal Mohammed Seyam, _epreparation.
245	1	0	_aIn Vitro Activity Of Colistin-Containing Antibiotic Combinations Against Colistin-Resistant Klebsiella Pneumoniae / _cBy Esraa Kamal Mohammed Seyam; Supervised By Prof. Dr. Iman Ezzat Wali, Ass. Prof. Dr. Noha Mahmoud Gohar, Dr. Sabrin El-kashef.
246	1	5	_aالنشاط المختبري لمزيج الكوليستين مع مضادات حيوية أخرى ضد الكلبسيلا الرئوية المقاومة للكوليستين /
264		0	_c2024.
300			_a98 pages : _billustrations ; _c25 cm. + _eCD.
336			_atext _2rda content
337			_aUnmediated _2rdamedia
338			_avolume _2rdacarrier
502			_aThesis (M.Sc.) -Cairo University, 2024.
504			_aBibliography: pages 73-98.
520			_aBackground: Multidrug-resistant (MDR) Klebsiella pneumoniae represents a growing threat to human health, causing infections associated with high morbidity and mortality. Since colistin is one of the few treatment options for treating these infections, colistin resistance represents a challenge due to the limited range of potentially available effective antibiotics. Antibiotic combination therapy has proven to be superior to monotherapy increasing the efficacy of the drugs and reducing toxicity and resistance. Objectives: The study aimed to evaluate the in vitro antibacterial activity of colistin-meropenem and colistin-amikacin combinations on MDR colistin- resistant Klebsiella pneumoniae. Methods: A total number of thirty colistin-resistant Klebsiella pneumoniae isolates were collected. Klebsiella pneumoniae isolates were identified by their colony morphology on MacConkey ’s agar and standard biochemical reactions. All isolates were tested for their susceptibility to antibiotics using the Kirby- Bauer disk diffusion method and proven to be multidrug -resistant. The colistin broth disk elution method confirmed colistin resistance in all isolates. The checkerboard method to test the antibiotic combinations was used. Results: The results revealed that colistin-meropenem combination had a better synergistic effect (73.3%) on MDR colistin -resistant Klebsiella pneumoniae isolates compared to colistin-amikacin combination (40%) with a statistically significant difference between them (P-value= 0.015). Conclusion: Antibiotic combination therapy is a promising option for treating MDR colistin-resistant Klebsiella pneumoniae.
520			_aالنشاط المختبري لمزيج الكوليستين مع مضادات حيوية أخرى ضد الكلبسيلا الرئوية المقاومة للكوليستين /
530			_aIssued also as CD
546			_aText in English and abstract in Arabic & English.
650		7	_aMedical Microbiology and Immunology _2qrmak
653		0	_aantibiotic combination _acheckerboard _acolistin resistance
700	0		_aIman Ezzat Wali _ethesis advisor.
700	0		_aNoha Mahmoud Gohar _ethesis advisor.
700	0		_aSabrin El-kashef _ethesis advisor.
900			_b01-01-2024 _cIman Ezzat Wali _cNoha Mahmoud Gohar _cSabrin El-kashef _UCairo University _FFaculty of Medicine _DDepartment of Medical Microbiology and Immunology
905			_aEman El gebaly _eEman Ghareb
942			_2ddc _cTH _e21 _n0
999			_c172283