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003			OSt
005			20250804120245.0
008			250625s2024 ua a|||frm||| 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda
041	0		_aeng _beng _bara
049			_aDeposit
082	0	4	_a615.19
092			_a615.19 _221
097			_aPh.D
099			_aCai01.08.05.Ph.D.2024.Ya.A.
100	0		_aYasmin Mohamed Youssef Emam, _epreparation.
245	1	0	_aAnalytical Study of Some Drugs Treating Respiratory Tract Diseases / _cBy Yasmin Mohamed Youssef Emam; Supervised By Prof. Dr. Marianne Alphonse Mahrouse,
246	1	5	_aدراسة تحليلية لبعض الأدوية المعالجة لأمراض الجهاز التنفسي /
264		0	_c2024.
300			_a145 pages : _billustrations ; _c25 cm. + _eCD.
336			_atext _2rda content
337			_aUnmediated _2rdamedia
338			_avolume _2rdacarrier
502			_aThesis (Ph.D)-Cairo University, 2024.
504			_aBibliography: pages 137-145.
520		3	_aIn this thesis, fast, simple and sensitive analytical techniques were established for determining various drugs that influence the respiratory system. These drugs include glycopyrronium bromide, indacaterol acetate, mometasone furoate and selexipag. The drugs were analyzed in bulk, in pharmaceutical formulations, binary mixtures, ternary mixtures, and in presence of impurities. Also, the greenness assessment was performed using four metrices NEMI, ESA, GAPI and AGREE, the results were compared with that of previously published ones A stability indicating reversed phase high performance liquid chromatography (RP- HPLC/UV) method was developed for the determination of selexipag in presence of its impurities. Another reversed phase high performance liquid chromatography (RP-HPLC/UV) method was developed and validated for the simultaneous determination of glycopyrronium bromide, indacaterol acetate and mometasone furoate in their fixed dose combination inhaler using experimental design technique by applying Plackett–Burman and face-centered composite design (FCC). Four sensitive and accurate UV-spectrophotometric methods were developed the simultaneous determination of indacaterol acetate and mometasone furoate. These methods were induced dual wavelength spectrophotometric method, absorption factor method coupled with modified amplitude subtraction method, first derivative spectrophotometric method coupled with amplitude factor method and first derivative ratio spectrophotometric method. At the end of each section, the validation parameters according to ICH guidelines were summarized. In addition, a statistical comparison between the results of the developed methods and that of the pharmacopeial or reported methods was performed and no significant difference were found.
520		3	_aتم فى هذه الرسالة إستحداث طرق تحليلية مختلفة على درجة من الدقة والسرعة والحساسية للتقدير الكمي لبعض الأدوية المؤثرة على الجهاز التنفسي وهي: سيليكسيباج وجلايكوبيرونيام بروميد وإينداكاتيرول أسيتات وموميتازون فوروات في صورتها النقية وفى مخاليطيها ومع نواتج تحللها وفى مستحضراتها الصيدلية ومقارنتها بالطرق الدستورية أو المرجعية. كما تم دراسة الأثر البيئي للطرق المقترحة باستخدام أربعة طرق وتمت مقارنة النتائج بنتائج الطرق المنشورة سابقا وأثبتت النتائج ان الطرق المقترحة صديقة للبيئة.
530			_aIssued also as CD
546			_aText in English and abstract in Arabic & English.
650		0	_aPharmaceutical Chemistry
653		1	_aGlycopyrronium bromide _aindacaterol acetate _amometasone furoate
700	0		_aMarianne Alphonse Mahrouse _ethesis advisor.
900			_b01-01-2024 _cMarianne Alphonse Mahrouse _UCairo University _FFaculty of Pharmacy _DDepartment of Pharmaceutical Chemistry
905			_aEman El gebaly _eEman Ghareb
942			_2ddc _cTH _e21 _n0
999			_c172732