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_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda |
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| 097 | _aPh.D | ||
| 099 | _aCai01.12.21.Ph.D.2024.Ab.P. | ||
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_aAbrar Fathy Mosaad Mohamed, _epreparation. |
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_aPhysiological Aspects Associated with Abortion in Zaraibi Goats : _bA Field Study / _cBy Abrar Fathy Mosaad Mohamed; Under Supervision Prof. Dr. Gamal Mohamed Morsy, Prof. Dr. Sayed Mohamed El-Nahkla. |
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_aالجوانب الفسيولوجية المرتبطة باإلجهاض فى الماعز الزرايبى : _bدراسة ميدانية / |
| 264 | 0 | _c2024. | |
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_a186 pages : _billustrations ; _c25 cm. + _eCD. |
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_atext _2rda content |
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_aUnmediated _2rdamedia |
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_avolume _2rdacarrier |
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| 502 | _aThesis (Ph.D)-Cairo University, 2024. | ||
| 504 | _aBibliography: pages 149-186. | ||
| 520 | 3 | _aThis study aimed to investigate the effect of non-environmental factors(Age, parity, and body weight) and the impact of synergetic effect of ambient lead (Pb) exposure and Temperature-Humidity index (THI) on incidence of abortion in Egyptian Zaraibi goats (C. hircus). To achieve this, 80 female goats (does) were mated with highly fertile male goats (bucks), at two periods according to the breeding time in Zaraibi goats. The first and second breeding season occurred in May and September 2018. The levels of PAG1, P4, and Pb in serum were estimated by enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA), and inductively coupled plasma mass spectrometry (ICP-MS) respectively while concentrations of hemoglobin content (Hb) in the blood and serum total proteins (STP) were measured using spectrophotometer. Statistically, cross-tabulation with a Chi-square test was applied to estimate the association (dependence or independence) of the ages, body weights, and parity variables of Zaraibi goats with the frequency(ies) of their birth cases (abortion or non-abortion) throughout the year and repeated measure two-way ANOVA, regression analysis, correlation coefficient, and receiver operating characteristic (ROC) curves were applied. Our present preliminary analysis showed an average Pb level of 5.0 mg/L of drinking water and 3.95 mg/kg of food which exceeded the allowable levels by UNESCO. The results showed that there was a significant direct relation between the parity of pregnant does and occurrence of abortion. The current data demonstrated that the levels of blood Pb in aborted goats were significantly higher than those in non-aborted goats throughout the gestation period and this was followed by significant decreases in levels of PAG1, P4, Fe, and STP. The threshold level of Pb required to cause abortion was ≥32.08 – 32.59 μg/dl, for PAG1 levels was ≤0.88 – 0.95 ng/ml, and P4 was ≤ 0.48- 0.69 ng/ml. Additionally, threshold levels of ≥11.08 - 12.34 ng/ml and ≥ 29.56 – 31.52 ng/ml for P4 and PAG1, respectively, were needed to deliver twins. In conclusion, elevated Temperature–Humidity Index (THI) and pollution induced increases in Pb bioavailability resulted in dramatic decreases in P4 and PAG1 levels, leading to abortions. PAG1 and P4 levels are also key factors in determining whether Zaraibi goats will give birth to twins. | |
| 520 | 3 | _aتم تصميم هذه الدراسة من أجل:1- ( تحديد درجة الارتباط بين المتغيرات التابعة )البروجسترون والهيموجلوبين والرصاص ومستويات الإجهاد التي تسبب الإجهاض. )PAG1( الحراري والبروتينات المرتبط بالحمل 2-( تقييم قوة الارتباط بين العوامل غير البيئية مثل )العمر ووزن الجسم وعدد (في P4 و 1 PAG مرات الولادة( وحدوث الإجهاض. ) 3- ( معرفة تركيزات P4 و PAG1 في دم الأم أثناء الحمل التي توقفت بسبب الإجهاض الطبيعي في الماعز الزرايبى.4- التنبؤ بمستويات P4 و PAG1 التي يمكن عندها إحداث الإجهاض والمستويات اللازمة للحصول على التوائم عن طريق تحليل .ROCوقد أظهرت الدراسة أن هناك علاقة طردية معنوية بين تركيزات الرصاص في سيرم دم الماعز المجهضة طول فترة الحمل. على العكس من ذلك، كان هناك ارتباط عكسي معنوي بين العوامل )الحديد - بروتينات المرتبطة بالحمل 1 – البروجسترون- البروتينات الكلية - الهيموجلوبين( في سيرم دم الماعز الزرايبى المجهضة خلال فترة الحمل. كان هناك ارتباط عكسي ملحوظ بين مستويات الرصاص وتركيزات (الحديد - بروتينات المرتبطة بالحمل 1-البروجسترون - البروتينات الكلية – الهيموجلوبين). كانت القيم التي تحفز الإجهاض في مستويات Pb و PAG1 و P4 هي 59,32 - 32,08 ميكروجرام/ديسيلتر - 0.95-0.88 نانوجرام/مل-0.48- 0,69 نانوجرام/مل على التوالي. كانت تركيزات البروتين المرتبطة بالحمل والبروجسترون المطلوبة للحصول على التوائم 31.52- 29,56نانوجرام/مل و 11,08- 12,34 نانوجرام/مل على التوالي. | |
| 530 | _aIssued also as CD | ||
| 546 | _aText in English and abstract in Arabic & English. | ||
| 650 | 0 | _aZoology | |
| 653 | 1 |
_aLead (Pb) _aTemperature-Humidity index (THI) _aProgesterone (P4) |
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| 653 | 1 |
_aالرصاص _aمؤشر درجة الحرارة والرطوبة _aالبرجسترون |
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_aamal Mohamed Morsy _ethesis advisor. |
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_aSayed Mohamed El-Nahkla _ethesis advisor. |
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_b01-01-2024 _camal Mohamed Morsy _cSayed Mohamed El-Nahkla _UCairo University _FFaculty of Science _DDepartment of Zoology |
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_aEman El gebaly _eEman Ghareb |
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_2ddc _cTH _e21 _n0 |
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| 999 | _c173546 | ||