000			05258namaa22004451i 4500
003			OSt
005			20250929123822.0
008			250909s2025 ua a|||frm||| 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC _dEG-GICUC _erda
041	0		_aeng _beng _bara
049			_aDeposit
082	0	4	_a615.19
092			_a615.19 _221
097			_aM.Sc
099			_aCai01.08.03.M.Sc.2025.Ma.A
100	0		_aMai Mohamed Talaat Ahmed, _epreparation.
245	1	0	_aApplication of advanced analytical techniques for quality assessment of selected drugs contain amino group / _cby Mai Mohamed Talaat Ahmed ; Supervision Prof. Dr. Hala Elsayed Zaazaa, Prof. Dr.Nahla Sayed Ismail Asst. Prof. Dr.Shereen Ahmed Boltia.
246	1	5	_aتطبيق تقنيات تحليلية متقدمة لتقييم جودة أدوية مختارة تحتوي على المجموعة الأمينية
264		0	_c2025.
300			_a54 pages : _billustrations ; _c25 cm. + _eCD.
336			_atext _2rda content
337			_aUnmediated _2rdamedia
338			_avolume _2rdacarrier
502			_aThesis (Ph.D)-Cairo University, 2025.
504			_aBibliography: pages 12-14.
520		3	_aThis thesis focuses on the quantitative analysis of certain drugs containing an amino group, such as Teriflunomide and Dorzolamide HCl, whether alone or in combination with Timolol Maleate, respectively. The objective of this research was to develop reliable, rapid, simple, sensitive, precise, and robust methods for determining the analytes with high accuracy and precision. These methods are intended for routine analysis in both bulk and pharmaceutical dosage forms. Two rapid, accurate, precise, and sensitive stability-indicating high-performance chromatographic methods were developed and validated for estimating Teriflunomide in the presence of its degradation products. The structures of the degradation products were elucidated using LC-MS. Additionally, two simple UV spectrophotometric methods were employed to determine Teriflunomide in the presence of its degradation products (pharmacopeial impurities). The first method involved measuring absorbance spectra from 200 to 400 nm, using one of the impurities as a divisor, followed by constructing the first derivative curve of the ratio spectrum. The second method was the dual wavelength method for the drug ratio spectra. Three innovative carbon paste electrodes were constructed to measure Dorzolamide HCl in both its active pharmaceutical ingredient (API) form and in pharmaceutical preparations containing Timolol Maleate. These included a conventional carbon paste electrode (I), a modified carbon paste electrode incorporating Silica (II), and another modified carbon paste electrode incorporating β-cyclodextrin (III). This research is based on the interaction between Dorzolamide HCl and phosphomolybdic acid to form an electroactive dorzolamide-phosphomolybdate ion exchanger, with dibutylphthalate used as a solvent mediator.
520		3	_a ﺗﺘﻨﺎول ھﺬه اﻟﺮﺳﺎﻟﺔ دراﺳﺔ ﺗﺤﻠﯿﻠﯿﺔ ﻟﺒﻌﺾ أدوﯾﺔ ﺗﺤﺘﻮي ﻋﻠﻰ ﻣﺠﻤﻮﻋﺔ الامينو ﺳﻮاء ﻣﻨﻔﺮدة أو ﻓﻲ مخاليط. وﻗﺪ ﺗﻢ اﺧﺘﯿﺎر ﺑﻌﺾ اﻟﻤﺮﻛﺒﺎت وھﻲ تيريفلونومايد بالاضافة الي خليط من الدورزولامايد هيدروكلوريد و تيمولول ماليات واﻟﮭﺪف ﻣﻦ ھﺬه اﻟﺮﺳﺎﻟﺔ ھﻮ اﺳﺘﻨﺒﺎط طﺮاﺋﻖ ﺟﺪﯾﺪة ﺗﺘﻤﯿﺰ ﺑﺎﻟﺒﺴﺎطﺔ واﻟﺪﻗﺔ ودرﺟﺔ اﻟﺤﺴﺎﺳﯿﺔ اﻟﻤﻨﺎﺳﺒﺔ ﻟﺘﺤﻠﯿﻞ ھﺬه اﻟﻤﺮﻛﺒﺎت ﻓﻲ وﺟﻮد ﻧﻮاﺗﺞ ﺗﺤﻠﻠﮭﺎ و/أو اﻟﺸﻮاﺋﺐ وﻛﺬﻟﻚ ﻓﻲ وﺟﻮد أدوﯾﺔ أﺧﺮى، وإﻣﻜﺎﻧﯿﺔ ﺗﻄﺒﯿﻖ اﻟﻄﺮاﺋﻖ اﻟﻤﺴﺘﺤﺪﺛﺔ ﻟﺘﺤﻠﯿﻞ اﻷدوﯾﺔ اﻟﻤﺨﺘﺎرة ﻓﻲ ﻣﺴﺘﺤﻀﺮاﺗﮭﺎ اﻟﺼﯿﺪﻟﯿﺔ وﻣﻘﺎرﻧﺘﮭﺎ ﺑﺎﻟﻄﺮاﺋﻖ اﻟﻤﺮﺟﻌﯿﺔ. ﺗﺤﺘــﻮي ھــﺬه اﻟﺮﺳــﺎﻟﺔ ﻋﻠــﻰ اربعة أﺟــﺰاء ﺗﺘﻀــﻤﻦ اﻟﺘــﺮاث اﻟﻌﻠﻤــﻲ واﻟﺪراﺳــﺔ اﻟﻌﻤﻠﯿــﺔ كما تحتوي علي اثنان و عشرون صورة و ثمانية عشر جدول وسبعون مرجع.
530			_aIssues also as CD.
546			_aText in English and abstract in Arabic & English.
650		0	_aPharmaceutical Chemistry
650		0	_aالكيمياء الصيدلية
653		1	_aRP-HPLC _aTeriflunomide _aStability indicating _aHPTLC _aValidation _aUV-spectrophotometric approaches _aderivative spectroscopy _a dual-wavelength ratio spectra
700	0		_aHala Elsayed Zaazaa _ethesis advisor.
700	0		_aNahla Sayed Ismail _ethesis advisor.
700	0		_aShereen Ahmed Boltia _ethesis advisor.
900			_b01-01-2025 _cHala Elsayed Zaazaa _cNahla Sayed Ismail _cShereen Ahmed Boltia _UCairo University _FFaculty of Pharmacy _DDepartment of Analytical Chemistry
905			_aShimaa _eEman Ghareb
942			_2ddc _cTH _e21 _n0
999			_c173947