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_beng
_cEG-GICUC
_dEG-GICUC
_erda
041 0 _aeng
_beng
_bara
049 _aDeposit
082 0 4 _a579.135
092 _a579.135
_221
097 _aM.Sc
099 _aCai01.12.05.M.Sc.2025.Na.E
100 0 _aNahla Muhammed Mahmoud Ahmed Ghazy,
_epreparation.
245 1 0 _aEfficacy of natural compounds and nanoparticles in control of dermatophytes /
_cby Nahla Muhammed Mahmoud Ahmed Ghazy ; Supervisor Prof. Dr. Mohsen Abou El- Ela Sayed, Prof. Dr. Assma Ali Hamouda.
246 1 5 _aكفاءة المركبات الطبيعية و الجزيئات النانوية فى مقاومة الفطريات الجلدية
264 0 _c2025.
300 _a59 pages :
_billustrations ;
_c25 cm. +
_eCD.
336 _atext
_2rda content
337 _aUnmediated
_2rdamedia
338 _avolume
_2rdacarrier
502 _aThesis (M.Sc)-Cairo University, 2025.
504 _aBibliography: pages 51-59.
520 3 _aDermatophyte infections globally account for twenty to twenty-five percent of fungal infections. Dermatophytes have begun exhibiting antifungal drug resistance, making it challenging to treat this particular infection. For this reason, researchers are looking for alternative treatments. Essential oils could be used as alternative solutions as they have been used for a long period to treat different infections. Nanoparticles are of tremendous interest in various applications including antifungal agents. With their inveterate antifungal action, many metallic nanoparticles have been utilized against human and plant pathogenic fungi. The research has demonstrated the antifungal efficacy of cinnamon, clove, lemongrass, tea tree, thyme, and garlic essential oils, and the impact of their combinations was assayed against Microsporum canis, Trichophyton tonsurans, T. violaceum, T. verrucosum and Epidermophyton floccosum. Polymerase Chain Reaction (PCR) – Restriction Fragment Length Polymorphism (RFLP) was used to identify the most prevalent M. canis. The accession number of M. canis was obtained as ON007275. All tested essential oils exhibited anti-dermatophytic action except garlic. A synergistic effect was attained by cinnamon + clove, cinnamon + lemongrass, clove + lemongrass, clove + tea tree, and thyme + tea tree combinations. Concerning antifungal activity, M. canis was the most susceptible dermatophytic species, except in the case of thyme T. violaceum, which was the most susceptible dermatophytic species. The maximum inhibition was recorded in the cases of cinnamon and cinnamon + lemon grass combination against M. canis. The least minimum inhibitory concentrations were attained by cinnamon and clove against M. canis, cinnamon + clove against M. cainis, and T. violaceum, and cinnamon + lemon grass against M. cainis, T. violaceum, T. verrucosum and E. floccosum. The least Minimum Fungicidal Concentration showed by cinnamon against M. canis, cinnamon + clove against M. canis, and T. violaceum, cinnamon + lemongrass against M. cains T. violaceum, T. verrucosum, and E. floccosum, clove + lemongrass against M. canis. The current research has tested the antifungal efficacy of eight novel synthesized metallic nanoparticle compounds: Ag0.49Cr2.51O4, Ag0.99Fe1.01O3, CoLa0.019Fe1.981O4, Co0.99Fe1.99O4, Ag0.99Cr1.01O2, Ca0.99Fe1.99O4, CoBi0.019Fe1.981O4, and Cu0.99Fe1.99O4 were synthesized by a flash auto-combustion reaction to evaluate synergistic potential of the Np's exhibited antifungal activity in combination with cinnamon, clove, lemongrass, tea tree and thyme essential oils extracted by Soxhlet method against M. canis, T. tonsurans, T. violaceum, T. verrucosum, and E. floccosum. Four nanoparticle compounds exhibited antifungal activity: silver chromite, silver iron oxide, cobalt lanthanum ferrite, and cobalt iron oxide against all tested dermatophytes. Maximum inhibition was recorded in the cases of Ag0.99Fe1.01O3, Ag0.99Fe1.01O3 + cinnamon against M. canis. Least minimum inhibitory concentrations were attained by Cinnamon against M. canis, Ag0.99Fe1.01O3 against M. canis, T. tonsurans, and T. violaceum, Ag0.99Fe1.01O3 + cinnamon against M. canis, T. violaceum and, T. verrucosum , Ag0.99Fe1.01O3 + clove, and Ag0.99Fe1.01O3 + lemongrass against M. canis. The study showed promising results regarding the synergistic antifungal efficacy of nanoparticle compounds combined with essential oils in the cases of Ag0.99Fe1.01O3 with cinnamon, Ag0.99Fe1.01O3 with clove and Ag0.99Fe1.01O3 with lemon grass against all tested dermatophytes
520 3 _aوأظهرت الدراسة وجود نشاط معادٍ للفطريات الجلدية في خمسة زيوت طيارة إستُخرجت بطريقة Soxhelet وهي: القرفة , القرنفل, حشيشة الليمون, شجرة الشاى, الزعتر ضد Microsporum canis, Trichophyton tonsurans, T. violaceum, T. verrucosum, and Epidermophyton floccosum وقد يكون الأثر التآزري المضاد للفطريات الناجم عن تشاركات الزيوت الطيارة إستراتيجية واعدة للتغلب على القيود العلاجية للأدوية المضادة للفطريات وتحقق أثر تآزري من خلال القرفة مع القرنفل، والقرفة مع حشيشة الليمون، والقرنفل مع حشيشة الليمون ، والقرنفل مع شجرة الشاي، والزعترمع شجرة الشاي. وقد أظهرت الدراسة وجود نشاط مضاد للفطريات الجلدية لأربعة مركابات نانوية جديدة مصنعة و هى: Ag0.49Cr2.51O4, Ag0.99Fe1.01O3, CoLa0.019Fe1.981O4, and Co0.99Fe1.99O4 ضد Microsporum canis, Trichophyton tonsurans, T. violaceum, T. verrucosum, and Epidermophyton floccosum , والنتائج الواعدة فيما يتعلق بالفعالية التآزرية المضادة للفطريات للزيوت الطيارة بالإتحاد مع المركبات النانوية في حالات :القرفة مع Ag0.99Fe1.01O3, القرنفل مع Ag0.99Fe1.01O3 , حشيشة الليمون مع Ag0.99Fe1.01O3 ضد Microsporum canis, Trichophyton tonsurans, T. violaceum, T. verrucosum, and Epidermophyton floccosum
530 _aIssues also as CD.
546 _aText in English and abstract in Arabic & English.
650 0 _aMycology
650 0 _aعلم الفطريات
653 1 _aAntifungal activity
_aEssential oils
_aNanoparticles
_aSynergistic combinations
_aMinimum inhibitory concentration (MIC)
_aDermatophytes
700 0 _aMohsen Abou El- Ela Sayed
_ethesis advisor.
700 0 _aAssma Ali Hamouda
_ethesis advisor.
900 _b01-01-2025
_cMohsen Abou El- Ela Sayed
_cAssma Ali Hamouda
_UCairo University
_FFaculty of Science
_DDepartment of Botany and Microbiology
905 _aShimaa
_eEman Ghareb
942 _2ddc
_cTH
_e21
_n0
999 _c175098